ArticleProceedings. Biological sciences2015
Detrimental effects of an autosomal selfish genetic element on sperm competitiveness in house mice.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 71 citations in OpenAlex.
- Recombination shapes the diversification of theeLife · 2026Article
- The metabolic costs of meiotic drive.Proceedings. Biological sciences · 2025Article
- Environmental and Genetic Traffic in the Journey from Sperm to Offspring.Biomolecules · 2023Review
- Meiotic drive adaptive testes enlargement during early development in the stalk-eyed fly.Biology letters · 2022Article
- A meiotic driver alters sperm form and function in house mice: a possible example of spite.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Article
- Meiotic drive in house mice: mechanisms, consequences, and insights for human biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
- Unbalanced selection: the challenge of maintaining a social polymorphism when a supergene is selfish.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Selfish migrants: How a meiotic driver is selected to increase dispersal.Journal of evolutionary biology · 2022Article
- The baculum affects paternity success of first but not second males in house mouse sperm competition.BMC ecology and evolution · 2021Article
- Experiments confirm a dispersive phenotype associated with a natural gene drive system.Royal Society open science · 2021Article
- Of mice and women: advances in mammalian sperm competition with a focus on the female perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Selfish genetic elements and male fertility.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Within-ejaculate sperm competition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Baculum shape and paternity success in house mice: evidence for genital coevolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- A test for meiotic drive in hybrids between Australian and Timor zebra finches.Ecology and evolution · 2020Article
- Resistance to natural and synthetic gene drive systems.Journal of evolutionary biology · 2020Review
- Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all display high gamete-killing efficiency.PLoS genetics · 2020Article
- Ancient gene drives: an evolutionary paradox.Proceedings. Biological sciences · 2019Article
- An X-linked meiotic drive allele has strong, recessive fitness costs in femaleProceedings. Biological sciences · 2019Article
- Effects of a male meiotic driver on male and female transcriptomes in the house mouse.Proceedings. Biological sciences · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Female multiple mating (polyandry) is widespread across many animal taxa and indirect genetic benefits are a major evolutionary force favouring polyandry. An incentive for polyandry arises when multiple mating leads to sperm competition that disadvantages sperm from genetically inferior mates. A reduction in genetic quality is associated with costly selfish genetic elements (SGEs), and studies in invertebrates have shown that males bearing sex ratio distorting SGEs are worse sperm competitors than wild-type males.We used a vertebrate model species to test whether females can avoid an autosomal SGE, the t haplotype, through polyandry. The t haplotype inhouse mice exhibits strong drive in t heterozygous males by affecting spermatogenesis and is associated with homozygous in utero lethality. We used controlled matings to test the effect of the t haplotype on sperm competitiveness. Regardless of mating order, t heterozygous males sired only 11% of zygotes when competing against wild-type males, suggesting a very strong effect of the t haplotype on sperm quality. We provide, to our knowledge,the first substantial evidence that polyandry ameliorates the harmful effects of an autosomal SGE arising through genetic incompatibility. We discuss potential mechanisms in our study species and the broader implications for the benefits of polyandry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.