ArticleJournal of cachexia, sarcopenia and muscle2015
Improved body weight and performance status and reduced serum PGE2 levels after nutritional intervention with a specific medical food in newly diagnosed patients with esophageal cancer or adenocarcinoma of the gastro-esophageal junction.
Article in Journal of cachexia, sarcopenia and muscle, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- High-protein oral nutritional supplement use in patients with cancer reduces complications and length of hospital stay: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Omega-3 Fatty Acid Supplementation and Its Impact on Systemic Inflammation and Body Weight in Patients With Cancer Cachexia-A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- Cancer cachexia: multilevel metabolic dysfunction.Nature metabolism · 2024Review
- The Role of Oral Nutritional Supplements in Head and Neck Cancer Patients Undergoing Chemoradiotherapy.Healthcare (Basel, Switzerland) · 2024Article
- Targeted nutritional intervention attenuates experimental lung cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2024Article
- Dose-Dependent Impacts of Omega-3 Fatty Acids Supplementation on Anthropometric Variables in Patients With Cancer: Results From a Systematic Review and Meta-Analysis of Randomized Clinical Trials.Clinical nutrition research · 2024Review
- Cancer cachexia: A scoping review on non-pharmacological interventions.Asia-Pacific journal of oncology nursing · 2024Article
- Identification of traumatic acid as a potential plasma biomarker for sarcopenia using a metabolomics-based approach.Journal of cachexia, sarcopenia and muscle · 2022Article
- Review
- Review
- Opportunistic body composition evaluation in patients with esophageal adenocarcinoma: association of survival withAnnals of nuclear medicine · 2020Article
- Time to jump on the bandwagon: the Journal of Cachexia, Sarcopenia and Muscle in 2018.Journal of cachexia, sarcopenia and muscle · 2018Article
- Computed tomography diagnosed cachexia and sarcopenia in 725 oncology patients: is nutritional screening capturing hidden malnutrition?Journal of cachexia, sarcopenia and muscle · 2018Article
- Oodles of opportunities: the Journal of Cachexia, Sarcopenia and Muscle in 2017.Journal of cachexia, sarcopenia and muscle · 2017Article
- The Efficacy of Oral Nutritional Intervention in Malnourished Cancer Patients: a Systemic Review.Clinical nutrition research · 2016Review
- Moving upwards - the journal of cachexia, sarcopenia and muscle in 2016.Journal of cachexia, sarcopenia and muscle · 2016Article
- Is Cancer Cachexia Attributed to Impairments in Basal or Postprandial Muscle Protein Metabolism?Nutrients · 2016Article
- Protein anabolic resistance in cancer: does it really exist?Current opinion in clinical nutrition and metabolic care · 2016Review
- Systemic Inflammation in Cachexia - Is Tumor Cytokine Expression Profile the Culprit?Frontiers in immunology · 2015Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe majority of cancer patients loses weight and becomes malnourished during the course of their disease. Metabolic alterations and reduced immune competence lead to wasting and an increased risk of infectious complications. In the present study, the effect of a nutritionally complete medical food, which is high in protein and leucine and enriched with fish oil and specific oligosaccharides, was investigated on immune function, nutritional status, and inflammation in patients with esophageal cancer and compared with routine care.
methodsIn this exploratory double-blind study, 64 newly diagnosed esophageal cancer patients were randomized. All patients received dietary counselling and dietary advice. In the Active group, all patients received the specific medical food for 4 weeks before the start of anticancer therapy. In the routine care control arm, patients with <5% weight loss received a non-caloric placebo product, and patients with weight loss ≥5% received an iso-caloric control product to secure blinding of the study. The required study parameters of body weight and performance status were recorded at baseline and after 4 weeks of nutritional intervention, and patients were asked to complete quality of life questionnaires. In addition, blood samples were taken for the measurement of several immune, nutritional, and safety-parameters.
resultsNo effect of the specific nutritional intervention could be detected on ex vivo stimulations of blood mononuclear cells. By contrast, body weight was significantly increased (P < 0.05) and ECOG performance status was improved after intervention with the specific medical food (P < 0.05). In addition, serum Prostaglandin E2 (PGE2) levels were significantly decreased in the specific medical food group and increased in the control group (P = 0.002).
conclusionsNutritional intervention with the specific medical food significantly increased body weight and improved performance status compared with routine care in newly diagnosed esophageal cancer patients. This effect was accompanied by significantly reduced serum PGE2 levels.
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