ArticleJournal of experimental botany2015
Antagonistic peptide technology for functional dissection of CLE peptides revisited.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- A CLE11b-CLE16 Signaling Relay Mediates Root-Shoot-Root Crosstalk for Drought Adaptation in Common Bean.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat.Nature communications · 2025Article
- Unlocking plant regeneration capacity: small signaling peptides are on aboard.Frontiers in plant science · 2025Article
- Antagonistic CLE peptide pathways shape root meristem tissue patterning.Nature plants · 2024Article
- Review
- Nitrogen-Activated CLV3/ESR-Related 4 (CLE4) Regulates Shoot, Root, and Stolon Growth in Potato.Plants (Basel, Switzerland) · 2023Article
- Peptidome and Transcriptome Analysis of Plant Peptides Involved inPlants (Basel, Switzerland) · 2023Article
- Functional characterization of C-TERMINALLY ENCODED PEPTIDE (CEP) family inPlant signaling & behavior · 2022Article
- Systematic Annotation RevealsCells · 2022Article
- WOX going on: CLE peptides in plant development.Current opinion in plant biology · 2021Review
- Processing and Formation of Bioactive CLE40 Peptide Are Controlled by Posttranslational Proline Hydroxylation.Plant physiology · 2020Article
- Peptide Signaling Pathways in Vascular Differentiation.Plant physiology · 2020Review
- The Systemin Signaling Cascade As Derived from Time Course Analyses of the Systemin-responsive Phosphoproteome.Molecular & cellular proteomics : MCP · 2019Article
- Nutrient-Responsive Small Signaling Peptides and Their Influence on the Root System Architecture.International journal of molecular sciences · 2018Review
- Peptides take centre stage in plant signaling. Preface.Journal of experimental botany · 2015Article
- Modulation of Arabidopsis and monocot root architecture by CLAVATA3/EMBRYO SURROUNDING REGION 26 peptide.Journal of experimental botany · 2015Article
- CLE19 expressed in the embryo regulates both cotyledon establishment and endosperm development in Arabidopsis.Journal of experimental botany · 2015Article
- Conservation of the abscission signaling peptide IDA during Angiosperm evolution: withstanding genome duplications and gain and loss of the receptors HAE/HSL2.Frontiers in plant science · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
In the Arabidopsis thaliana genome, over 1000 putative genes encoding small, presumably secreted, signalling peptides can be recognized. However, a major obstacle in identifying the function of genes encoding small signalling peptides is the limited number of available loss-of-function mutants. To overcome this, a promising new tool, antagonistic peptide technology, was recently developed. Here, this antagonistic peptide technology was tested on selected CLE peptides and the related IDA peptide and its usefulness in the context of studies of peptide function discussed. Based on the analyses, it was concluded that the antagonistic peptide approach is not the ultimate means to overcome redundancy or lack of loss-of-function lines. However, information collected using antagonistic peptide approaches (in the broad sense) can be very useful, but these approaches do not work in all cases and require a deep insight on the interaction between the ligand and its receptor to be successful. This, as well as peptide ligand structure considerations, should be taken into account before ordering a wide range of synthetic peptide variants and/or generating transgenic plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.