Evidence map›Paper›PMID 26135869›Full record

ArticleJournal of clinical microbiology2015

Comparison of Three Commercial Molecular Assays for Detection of Rifampin and Isoniazid Resistance among Mycobacterium tuberculosis Isolates in a High-HIV-Prevalence Setting.

K Strydom, F Ismail, M M Z Matabane, O Onwuegbuna, S V Omar, N Ismail

Open access · bronzeAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 4 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

K StrydomDepartment of Medical Microbiology, University of Pretoria, Pretoria, South Africa National Health Laboratory Services, Tshwane Academic Division, Pretoria, South Africa strydom.kathy@gmail.com.
F IsmailDepartment of Medical Microbiology, University of Pretoria, Pretoria, South Africa National Health Laboratory Services, Tshwane Academic Division, Pretoria, South Africa.
M M Z MatabaneDepartment of Medical Microbiology, University of Pretoria, Pretoria, South Africa National Health Laboratory Services, Tshwane Academic Division, Pretoria, South Africa.
O OnwuegbunaNational Health Laboratory Services, Tshwane Academic Division, Pretoria, South Africa.
S V OmarNational Institute for Communicable Diseases: Centre for TB, Johannesburg, South Africa.
N IsmailDepartment of Medical Microbiology, University of Pretoria, Pretoria, South Africa National Institute for Communicable Diseases: Centre for TB, Johannesburg, South Africa.
University of Pretoria · ZANational Health Laboratory Service · ZANational Institute for Communicable Diseases

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a head-to-head comparison of the MTBDRplus version 2.0 (Hain Lifescience), the Xpert MTB/RIF (Cepheid), and the Anyplex MTB/NTM (Seegene) assays, we demonstrated equal sensitivity (59/61; 96.7%) and specificity (53/54; 98.1%) for detecting rifampin resistance with further analysis of discordances. The Xpert assay does not detect isoniazid resistance while the Anyplex assay showed high false positivity.

Indexed as

Drug Resistance, BacterialAntitubercular AgentsGenotyping TechniquesHIV InfectionsHumansIsoniazidMicrobial Sensitivity TestsMycobacterium tuberculosisRifampinSensitivity and SpecificityTuberculosisAntitubercular AgentsIsoniazidRifampin

Identifiers

PMID26135869
PMCPMC4540900
OpenAlexW1782173299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.