ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society2015
Arachidonic acid-derived signaling lipids and functions in impaired healing.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Dietary omega-6 lipids promote postinjury aberrant bone formation in obesity.The Journal of clinical investigation · 2026Article
- Platelets cause microvascular occlusion and delayed neurological deficits after subarachnoid hemorrhage in mice.Experimental & molecular medicine · 2026Article
- A Systemic Pathophysiological View of Sensitive Skin Revealed by Proteomics: Beyond Barrier and Inflammation.Journal of cosmetic dermatology · 2026Article
- Natural protection against oxidative stress in human skin melanocytes.Communications biology · 2025Review
- Unraveling the molecular dynamics of wound healing: integrating spatially resolved lipidomics and temporally resolved proteomics.Analytical and bioanalytical chemistry · 2025Article
- Delayed Immune Response Upon Injury in Diabetic Wounds Impedes Healing.Immunity, inflammation and disease · 2025Article
- The Role of Linoleic Acid in Skin and Hair Health: A Review.International journal of molecular sciences · 2024Review
- Modeling enzyme competition in eicosanoid metabolism in macrophage cells using a cybernetic framework.Journal of lipid research · 2024Article
- Arachidonic acid metabolism in health and disease.MedComm · 2023Review
- Skewing cPLAScience signaling · 2023Article
- Progression of prostate cancer reprograms MYC-mediated lipid metabolism via lysine methyltransferase 2A.Discover oncology · 2022Article
- Evidence for Systemic Reactive Oxygen Species in UVB-mediated Microvesicle Formation.Photochemistry and photobiology · 2022Article
- The microbiome mediates epiphyseal bone loss and metabolomic changes after acute joint trauma in mice.Osteoarthritis and cartilage · 2021Article
- Bioactive Sugarcane Lipids in a Circular Economy Context.Foods (Basel, Switzerland) · 2021Review
- Examination of lipid profiles in abdominal fascial healing using MALDI-TOF to identify potential therapeutic targets.Journal of mass spectrometry and advances in the clinical lab · 2021Article
- The complex role of prostaglandin EAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2021Review
- Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.Cell stem cell · 2020Article
- The Enigma of Bioactivity and Toxicity of Botanical Oils for Skin Care.Frontiers in pharmacology · 2020Review
- The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase AScience signaling · 2019Article
- A rapid and adaptable lipidomics method for quantitative UPLC-mass spectrometric analysis of phosphatidylethanolamine and phosphatidylcholineAnalytical methods : advancing methods and applications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Very little is known about lipid function during wound healing, and much less during impaired healing. Such understanding will help identify what roles lipid signaling plays in the development of impaired/chronic wounds. We took a lipidomics approach to study the alterations in lipid profile in the LIGHT(-/-) mouse model of impaired healing which has characteristics that resemble those of impaired/chronic wounds in humans, including high levels of oxidative stress, excess inflammation, increased extracellular matrix degradation and blood vessels with fibrin cuffs. The latter suggests excess coagulation and potentially increased platelet aggregation. We show here that in these impaired wounds there is an imbalance in the arachidonic acid (AA) derived eicosonoids that mediate or modulate inflammatory reactions and platelet aggregation. In the LIGHT(-/-) impaired wounds there is a significant increase in enzymatically derived breakdown products of AA. We found that early after injury there was a significant increase in the eicosanoids 11-, 12-, and 15-hydroxyeicosa-tetranoic acid, and the proinflammatory leukotrienes (LTD4 and LTE) and prostaglandins (PGE2 and PGF2α ). Some of these eicosanoids also promote platelet aggregation. This led us to examine the levels of other eicosanoids known to be involved in the latter process. We found that thromboxane (TXA2 /B2 ), and prostacyclins 6kPGF1α are elevated shortly after wounding and in some cases during healing. To determine whether they have an impact in platelet aggregation and hemostasis, we tested LIGHT(-/-) mouse wounds for these two parameters and found that, indeed, platelet aggregation and hemostasis are enhanced in these mice when compared with the control C57BL/6 mice. Understanding lipid signaling in impaired wounds can potentially lead to development of new therapeutics or in using existing nonsteroidal anti-inflammatory agents to help correct the course of healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.