Evidence map›Paper›PMID 26135474›Full record

ArticleACS nano2015

Construction of RNA-Quantum Dot Chimera for Nanoscale Resistive Biomemory Application.

Taek Lee, Ajay Kumar Yagati, Fengmei Pi, Ashwani Sharma, Jeong-Woo Choi, Peixuan Guo

Abstract read
In one paragraph

Article in ACS nano, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
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  3. Article
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  7. Article
  8. Building memory devices from biocomposite electronic materials.Science and technology of advanced materials · 2020
    Review
  9. Review
  10. Review
  11. Construction of RNA nanotubes.Nano research · 2019
    Article
  12. Review
  13. HNano convergence · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Controllable self-assembly of RNA dendrimers.Nanomedicine : nanotechnology, biology, and medicine · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Taek Lee†Nanobiotechnology Center, Markey Cancer Center, and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, United States.
Ajay Kumar Yagati‡Department of Biomedical Engineering, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon 406-799, Republic of Korea.
Fengmei Pi†Nanobiotechnology Center, Markey Cancer Center, and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, United States.
Ashwani Sharma†Nanobiotechnology Center, Markey Cancer Center, and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, United States.
Jeong-Woo Choi§Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul 121-742, Republic of Korea.
Peixuan Guo†Nanobiotechnology Center, Markey Cancer Center, and Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, United States.
Markey Cancer Center · USUniversity of Kentucky · USGachon University · KRSogang University · KR

Funding

Phi29 Motor Nanopore for Single Molecule Sensing and dsDNA FingerprintingR01EB012135 · NIBIB · UNIVERSITY OF KENTUCKY · PI GUO, PEIXUAN · 2011 to 2019
$2.6M
RNA Nanotechnology in Cancer TherapyU01CA151648 · NCI · UNIVERSITY OF KENTUCKY · PI GUO, PEIXUAN, LI, HENRY · 2010 to 2014
$2.1M
NCI NIH HHS U01 CA151648NCI NIH HHS U01CA151648NIBIB NIH HHS R01 EB012135NIBIB NIH HHS R01EB012135
6 · The paper itself

Abstract

RNA nanotechnology offers advantages to construct thermally and chemically stable nanoparticles with well-defined shape and structure. Here we report the development of an RNA-QD (quantum dot) chimera for resistive biomolecular memory application. Each QD holds two copies of the pRNA three-way junction (pRNA-3WJ) of the bacteriophage phi29 DNA packaging motor. The fixed quantity of two RNAs per QD was achieved by immobilizing the pRNA-3WJ with a Sephadex aptamer for resin binding. Two thiolated pRNA-3WJ serve as two feet of the chimera that stand on the gold plate. The RNA nanostructure served as both an insulator and a mediator to provide defined distance between the QD and gold. Immobilization of the chimera nanoparticle was confirmed with scanning tunneling microscopy. As revealed by scanning tunneling spectroscopy, the conjugated pRNA-3WJ-QD chimera exhibited an excellent electrical bistability signal for biomolecular memory function, demonstrating great potential for the development of resistive biomolecular memory and a nano-bio-inspired electronic device for information processing and computing.

Indexed as

Aptamers, NucleotideNanotechnologyQuantum DotsRNA, ViralAptamers, NucleotideRNA, Viralbiomolecular electronicsnanoscale resistive biomolecular memoryphi29 DNA packaging motorpRNA−quantum dot chimeraRNA nanotechnology

Identifiers

PMID26135474
PMCPMC4642448
OpenAlexW2412058059

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.