Evidence map›Paper›PMID 26135470›Full record

ArticleScientific reports2015

Carbon Quantum Dots for Zebrafish Fluorescence Imaging.

Yan-Fei Kang, Yu-Hao Li, Yang-Wu Fang, Yang Xu, Xiao-Mi Wei, Xue-Bo Yin

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 229 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yan-Fei KangResearch Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin Key laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
Yu-Hao LiTianjin Key Laboratory of Tumor Microenviroment and Neurovascular Regulation, School of Medicine, Nankai University, Tianjin, 300071, China.
Yang-Wu FangTianjin Key Laboratory of Tumor Microenviroment and Neurovascular Regulation, School of Medicine, Nankai University, Tianjin, 300071, China.
Yang XuResearch Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin Key laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
Xiao-Mi WeiResearch Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin Key laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
Xue-Bo YinResearch Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin Key laboratory of Biosensing and Molecular Recognition, State Key Laboratory of Medicinal Chemical Biology, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
Collaborative Innovation Center of Chemical Science and Engineering Tianjin · CNNankai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon quantum dots (C-QDs) are becoming a desirable alternative to metal-based QDs and dye probes owing to their high biocompatibility, low toxicity, ease of preparation, and unique photophysical properties. Herein, we describe fluorescence bioimaging of zebrafish using C-QDs as probe in terms of the preparation of C-QDs, zebrafish husbandry, embryo harvesting, and introduction of C-QDs into embryos and larvae by soaking and microinjection. The multicolor of C-QDs was validated with their imaging for zebrafish embryo. The distribution of C-QDs in zebrafish embryos and larvae were successfully observed from their fluorescence emission. the bio-toxicity of C-QDs was tested with zebrafish as model and C-QDs do not interfere to the development of zebrafish embryo. All of the results confirmed the high biocompatibility and low toxicity of C-QDs as imaging probe. The absorption, distribution, metabolism and excretion route (ADME) of C-QDs in zebrafish was revealed by their distribution. Our work provides the useful information for the researchers interested in studying with zebrafish as a model and the applications of C-QDs. The operations related zebrafish are suitable for the study of the toxicity, adverse effects, transport, and biocompatibility of nanomaterials as well as for drug screening with zebrafish as model.

Indexed as

AnimalsCarbonEmbryo, NonmammalianFemaleFluorescent DyesMaleMicroinjectionsMicroscopy, FluorescenceQuantum DotsZebrafishCarbonFluorescent Dyes

Identifiers

PMID26135470
PMCPMC4488761
OpenAlexW2273535130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.