Evidence map›Paper›PMID 26135463›Full record

Trial reportHerz2015

Comparison of three diuretic treatment strategies for patients with acute decompensated heart failure.

Çağrı Yayla, Ahmet Akyel, Uğur Canpolat, Kadriye Gayretli Yayla, Azmi Eyiol, Mehmet Kadri Akboğa, Sedat Türkoğlu, Yusuf Tavil, Bülent Boyacı, Atiye Çengel

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Herz, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 10 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 10 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Çağrı YaylaDepartment of Cardiology, Türkiye Yüksek Ihtisas Education and Research Hospital, Ankara, Turkey. cagriyayla@gmail.com.
Ahmet AkyelDepartment of Cardiology, Dişkapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Uğur CanpolatDepartment of Cardiology, Türkiye Yüksek Ihtisas Education and Research Hospital, Ankara, Turkey.
Kadriye Gayretli YaylaDepartment of Cardiology, Dişkapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Azmi EyiolDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey.
Mehmet Kadri AkboğaDepartment of Cardiology, Türkiye Yüksek Ihtisas Education and Research Hospital, Ankara, Turkey.
Sedat TürkoğluDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey.
Yusuf TavilDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey.
Bülent BoyacıDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey.
Atiye ÇengelDepartment of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey.
Gazi University · TRTürkiye Yüksek İhtisas Hastanesi · TRDışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are few prospective data available for establishing a standard diuretic administration regimen for patients with acute decompensated heart failure (ADHF). We aimed to assess the safety and efficacy of three regimens of furosemide administration in patients with ADHF with regard to diuresis, renal functions, and in-hospital outcomes.

methodsA total of 43 patients who presented with ADHF were randomized into three groups: (a) continuous infusion (cIV) of 160 mg furosemide for 16 h/day (n = 15); (b) bolus injections (bI) of 80 mg furosemide twice a day (n = 14); (c) and administration of 160 mg furosemide plus hypertonic saline solution (HSS) as an infusion for 30 min once a day (n = 14). All regimens were continued for 48 h. Study endpoints were negative fluid balance assessed by loss of body weight, change in the serum creatinine (baseline to 48 h and baseline to compensated state), and length of hospitalization.

resultsThere was no significant difference in the mean change in serum creatinine level at the end of 48 h between groups (p = 0.08). There was also no significant difference among groups regarding loss of body weight (p = 0.66). A significantly shorter hospitalization was observed in patients treated with HSS compared with the other groups (cIV group 6.6 ± 3.4 days vs. bI group 7.9 ± 4.1 days vs. HSS group 3.7 ± 1.3 days; p < 0.01).

conclusionAll three furosemide regimens have similar renal safety and efficacy measures. However, administration of furosemide plus HSS may be the preferred diuretic strategy because of its shorter hospital stay.

Indexed as

Acute DiseaseAdministration, OralAdrenergic beta-AntagonistsAgedAngiotensin-Converting Enzyme InhibitorsDiureticsFemaleFurosemideHeart FailureHumansMaleMineralocorticoid Receptor AntagonistsProspective StudiesTreatment OutcomeAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsDiureticsFurosemideMineralocorticoid Receptor AntagonistsAcute heart failure syndromeDiuretic therapyFurosemideHospitalizationRenal safety profile

Identifiers

PMID26135463
OpenAlexW1862837576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.