Evidence map›Paper›PMID 26135451›Full record

ArticleNature2015

Sex reversal triggers the rapid transition from genetic to temperature-dependent sex.

Clare E Holleley, Denis O'Meally, Stephen D Sarre, Jennifer A Marshall Graves, Tariq Ezaz, Kazumi Matsubara, Bhumika Azad, Xiuwen Zhang, Arthur Georges

Abstract read
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In one paragraph

Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Insights intoBiomolecules · 2025
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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Clare E HolleleyInstitute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia.
Denis O'MeallyInstitute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia.
Stephen D SarreInstitute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia.
Jennifer A Marshall Graves1] Institute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia [2] School of Life Science, La Trobe University, Melbourne, Victoria 3086, Australia.
Tariq EzazInstitute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia.
Kazumi MatsubaraInstitute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia.
Bhumika AzadInstitute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia.
Xiuwen ZhangInstitute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia.
Arthur GeorgesInstitute for Applied Ecology, University of Canberra, Canberra, Australian Capital Territory 2601, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sex determination in animals is amazingly plastic. Vertebrates display contrasting strategies ranging from complete genetic control of sex (genotypic sex determination) to environmentally determined sex (for example, temperature-dependent sex determination). Phylogenetic analyses suggest frequent evolutionary transitions between genotypic and temperature-dependent sex determination in environmentally sensitive lineages, including reptiles. These transitions are thought to involve a genotypic system becoming sensitive to temperature, with sex determined by gene-environment interactions. Most mechanistic models of transitions invoke a role for sex reversal. Sex reversal has not yet been demonstrated in nature for any amniote, although it occurs in fish and rarely in amphibians. Here we make the first report of reptile sex reversal in the wild, in the Australian bearded dragon (Pogona vitticeps), and use sex-reversed animals to experimentally induce a rapid transition from genotypic to temperature-dependent sex determination. Controlled mating of normal males to sex-reversed females produces viable and fertile offspring whose phenotypic sex is determined solely by temperature (temperature-dependent sex determination). The W sex chromosome is eliminated from this lineage in the first generation. The instantaneous creation of a lineage of ZZ temperature-sensitive animals reveals a novel, climate-induced pathway for the rapid transition between genetic and temperature-dependent sex determination, and adds to concern about adaptation to rapid global climate change.

Indexed as

Adaptation, PhysiologicalTemperatureAnimalsAustraliaFemaleMaleMolecular Sequence DataReptilesSex ChromosomesSex Determination ProcessesSex Ratio

Identifiers

PMID26135451

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.