ArticlePLoS neglected tropical diseases2015
Suppression of a Field Population of Aedes aegypti in Brazil by Sustained Release of Transgenic Male Mosquitoes.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 275 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
275 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of Aedes aegypti control trials suggests publication bias related to author disclosure of conflicts of interest.PLoS neglected tropical diseases · 2026Pooled it
- A Systematic Review of Mathematical Models of Dengue Transmission and Vector Control: 2010-2020.Viruses · 2023Pooled it
- Split suppression gene drives reveal a design tradeoff between inheritance and reproductive load inbioRxiv : the preprint server for biology · 2026Article
- Insecticide susceptibility and knockdown resistance (Kdr) mutations (F1534C and V1016I) in Aedes aegypti populations from Dar es Salaam, Tanzania.Parasites & vectors · 2026Article
- Variance partitioning reveals contrasting random effect contributions to the density and species composition of malaria-transmitting mosquitoes in western Burkina Faso.Parasites & vectors · 2026Article
- Overview of Chikungunya Virus Pathogenesis, Genome Variation, Epidemiology, and Control.Virus research · 2026Review
- Modelling, analysis and optimal control of Zika virus transmission dynamics based on sterile insect technique.Infectious Disease Modelling · 2026Article
- Addition of a single bacterial isolate to conventional larval rearing water can impact wing size and longevity in adult malebioRxiv : the preprint server for biology · 2026Article
- Review
- Managing and controlling diseases transmitted by Aedes mosquitoes: a review on best practices.Tropical medicine and health · 2026Review
- Snail 3G: genomics, genetics, and gene-editing ofFrontiers in genetics · 2026Review
- Article
- Advances in male sex separation for the support of mosquito control programs.Frontiers in insect science · 2026Review
- Extended time to maturity in Anopheles coluzzii: Implications of late egg hatch for vector control and transgene fitness.Medical and veterinary entomology · 2025Article
- CRISPR/Cas genome editing, functional genomics, and diagnostics for parasitic helminths.International journal for parasitology · 2025Review
- Phenol and chromone compounds forPharmaceutical science advances · 2025Article
- Successful insertion and expression of a tetracycline transactivator in Anopheles stephensi associated with increased egg production and decreased hatching rate.Parasites & vectors · 2025Article
- Requirements for designing cluster randomised control trials to detect suppression of malaria vector population densities.BMC biology · 2025Article
- GeneDrive.jl: A decision tool to optimize biological vector control strategies under climate change.PLoS computational biology · 2025Article
- Insights on the sex determination, vector capacity and ecological biology from a chromosomal level genome of vector mosquito, Armigeres subulbatus.Infectious diseases of poverty · 2025Article
215 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
The increasing burden of dengue, and the relative failure of traditional vector control programs highlight the need to develop new control methods. SIT using self-limiting genetic technology is one such promising method. A self-limiting strain of Aedes aegypti, OX513A, has already reached the stage of field evaluation. Sustained releases of OX513A Ae. aegypti males led to 80% suppression of a target wild Ae. aegypti population in the Cayman Islands in 2010. Here we describe sustained series of field releases of OX513A Ae. aegypti males in a suburb of Juazeiro, Bahia, Brazil. This study spanned over a year and reduced the local Ae. aegypti population by 95% (95% CI: 92.2%-97.5%) based on adult trap data and 81% (95% CI: 74.9-85.2%) based on ovitrap indices compared to the adjacent no-release control area. The mating competitiveness of the released males (0.031; 95% CI: 0.025-0.036) was similar to that estimated in the Cayman trials (0.059; 95% CI: 0.011-0.210), indicating that environmental and target-strain differences had little impact on the mating success of the OX513A males. We conclude that sustained release of OX513A males may be an effective and widely useful method for suppression of the key dengue vector Ae. aegypti. The observed level of suppression would likely be sufficient to prevent dengue epidemics in the locality tested and other areas with similar or lower transmission.
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