ArticlePediatric nephrology (Berlin, Germany)2015
Proteinuria caused by glomerular hypertension during adolescence associated with extremely premature birth: a report of two cases.
Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Young adults born moderately to extremely preterm have higher eGFR and cystatin C compared to young adults born at term.Pediatric nephrology (Berlin, Germany) · 2026Article
- Chronic kidney disease associated with extremely premature birth and extremely low birth weight may progress through the burden of growth.CEN case reports · 2025Article
- Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023Review
- Perinatal factors contributing to chronic kidney disease in a cohort of Japanese children with very low birth weight.Pediatric nephrology (Berlin, Germany) · 2021Article
- Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2020Review
- Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Biochemical Markers of Renal Hypoperfusion, Hemoconcentration, and Proteinuria after Extreme Physical Exercise.Medicina (Kaunas, Lithuania) · 2019Article
- Blood Pressure Trajectories from Childhood to Adolescence in Pediatric Hypertension.Korean circulation journal · 2019Review
- Polycythemia, capillary rarefaction, and focal glomerulosclerosis in two adolescents born extremely low birth weight and premature.Pediatric nephrology (Berlin, Germany) · 2017Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrematurity and low birth weight are risk factors for the future development of chronic kidney disease (CKD) and hypertension caused by fewer nephrons with limited filtration surface area. Few reports to date have evaluated their clinical backgrounds and pathological findings, including glomerular hypertension and focal segmental glomerulosclerosis. CASE-DIAGNOSIS/TREATMENT: This report describes two patients, a 15-year-old girl (patient 1), with a birth weight of 618 g and a gestational age of 24 weeks, and a 14-year-old boy (patient 2), with a birth weight of 842 g and a gestational age at 25 weeks. Both had a birth weight appropriate for gestational age. Both were first diagnosed with proteinuria during adolescence, and patient 2 also had hypertension. Pathological findings included glomerulomegaly in both and hypertrophy of the juxtaglomerular apparatus and perihilar glomerulosclerosis in patient 1, suggesting glomerular hypertension. Treatment with lisinopril resulted in the immediate disappearance of proteinuria. Renal dysfunction was observed in both patients, but neither showed evidence of severe aggravation after a follow-up of 5 or 6 years.
conclusionsProteinuria in both patients was caused by glomerular hypertension with hyperfiltration. Extremely preterm birth itself may be a risk factor for future CKD. Long-term follow-up of patients born prematurely and at low birth weight, including urinalysis and blood pressure measurements, is necessary to diagnose and treat late renal complications.
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