ReviewThe Journal of bone and joint surgery. American volume2015
Heterotopic Ossification: Basic-Science Principles and Clinical Correlates.
Review in The Journal of bone and joint surgery. American volume, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03724422 (Prophylaxis Low-Dose Radiation Therapy for Heterotopic Ossification in Distal Humerus Fractures), which is not on this map. Cited by 192 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylaxis Low-Dose Radiation Therapy for Heterotopic Ossification in Distal Humerus Fractures
Who cites it
192 citing papers in PubMed, 1 synthesis or guideline pooled it, 377 citations in OpenAlex.
- Heterotopic ossification following COVID-19 infections: systematic literature review of case reports and case series.BMC musculoskeletal disorders · 2024Pooled it
- Heterotopic ossifications following an anterior approach total ankle arthroplasty: incidence, distribution, and correlation with rehabilitation.Musculoskeletal surgery · 2026Article
- Total elbow arthroplasty for unreconstructible distal humerus fracture sequelae in patients less than 40 year old. Long-term outcomes.Journal of shoulder and elbow arthroplasty · 2026Article
- Extensive Post-Traumatic Heterotopic Ossification with Multi-joint Involvement: A Case Report.Journal of orthopaedic case reports · 2026Article
- Pelvic heterotopic ossification causing bladder compression: a rare post-traumatic case report.International journal of surgery case reports · 2026Article
- Tendon stem/progenitor cells in heterotopic ossification: functional regulation, molecular mechanisms and targeted therapeutic strategies.Journal of orthopaedic translation · 2026Review
- Bone fragility in a post-intestinal transplant patient with mesenteric heterotopic ossification.JBMR plus · 2026Article
- Multifocal Skeletal Muscle Mineralisation Following Severe Trauma and Prolonged Critical Illness: A Case Report.Cureus · 2026Article
- Preoperative arterial and venous embolization of heterotopic ossification of the hip: a case-control study.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Postoperative nonsteroidal anti-inflammatory drug prophylaxis for elbow heterotopic ossification: a systematic review and meta-analysis comparing COX-2 selective and nonselective inhibitors.JSES reviews, reports, and techniques · 2026Review
- The neuro-skeletal crosstalk: Mechanisms, clinical implications, and smart material interventions.Journal of orthopaedic translation · 2026Review
- Severe glenohumeral ankylosis following revision reverse shoulder arthroplasty.JSES reviews, reports, and techniques · 2026Article
- The IL-1β/NETs/AIM2 axis participates in the formation of trauma-induced heterotopic ossification by orchestrating crosstalk between neutrophils and macrophages.Journal of advanced research · 2026Article
- Cytokine array analyses and osteogenic potential of plasma from patients with traumatic brain-/spinal cord injury: predictive markers of heterotopic ossification?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Heterotopic Ossification After Acute Acromioclavicular Joint Dislocation-Effect on Radiographic and Clinical Outcomes.Orthopaedic journal of sports medicine · 2026Article
- Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization.Bone research · 2026Article
- Heterotopic Ossification at Tracker Pin Sites Following Robotic-Assisted Total Knee Arthroplasty.Case reports in orthopedics · 2026Article
- Cranial Defect Reconstruction With Custom 3D-Printed Hydroxyapatite Scaffolds Augmented With rhBMP-2 or Dipyridamole in a Nonhuman Primate Model.Journal of tissue engineering and regenerative medicine · 2026Article
- Article
- Carnosic acid serves as a dual Nrf2 activator and PTEN/AKT suppressor to inhibit traumatic heterotopic ossification.Stem cell research & therapy · 2025Article
132 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedErratum.2015 · Wong, Victor C [corrected to Wong, Victor W]
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
➤ Heterotopic ossification occurs most commonly after joint arthroplasty, spinal cord injury, traumatic brain injury, blast trauma, elbow and acetabular fractures, and thermal injury.➤ The conversion of progenitor cells to osteogenic precursor cells as a result of cell-mediated interactions with the local tissue environment is affected by oxygen tension, pH, availability of micronutrients, and mechanical stimuli, and leads to heterotopic ossification.➤ Radiation and certain nonsteroidal anti-inflammatory medications are important methods of prophylaxis against heterotopic ossification.➤ Well-planned surgical excision can improve patient outcomes regardless of the joint involved or the initial cause of injury.➤ Future therapeutic strategies are focused on targeted inhibition of local factors and signaling pathways that catalyze ectopic bone formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.