ArticleInvestigative radiology2015
Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results.
Article in Investigative radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Targeted Microbubbles for Drug, Gene, and Cell Delivery in Therapy and Immunotherapy.Pharmaceutics · 2023Review
- Exosomes and ultrasound: The future of theranostic applications.Materials today. Bio · 2023Review
- Monodispersity Increases Adhesion Efficiency and Specificity for Ultrasound-Targeted Microbubbles.ACS biomaterials science & engineering · 2023Article
- Cavitation Characterization of Size-Isolated Microbubbles in a Vessel Phantom Using Focused Ultrasound.Pharmaceutics · 2022Article
- Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020Review
- Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.Ultrasound in medicine & biology · 2020Review
- Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications.Theranostics · 2020Review
- Validation of Normalized Singular Spectrum Area as a Classifier for Molecularly Targeted Microbubble Adherence.Ultrasound in medicine & biology · 2019Article
- Super-Resolution Contrast-Enhanced Ultrasound Methodology for the Identification of In Vivo Vascular Dynamics in 2D.Investigative radiology · 2019Article
- Production of acoustic radiation force using ultrasound: methods and applications.Expert review of medical devices · 2018Review
- Ultrasound Molecular Imaging of Inflammation in Mouse Abdominal Aorta.Investigative radiology · 2017Article
- [Evaluation of renal tissue ischemia-reperfusion injury with ultrasound radiation force and targeted microbubbles].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- The Use of Acoustic Radiation Force Decorrelation-Weighted Pulse Inversion for Enhanced Ultrasound Contrast Imaging.Investigative radiology · 2017Article
- Pipe Phantoms With Applications in Molecular Imaging and System Characterization.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Article
- Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model: How Little Can We See?Investigative radiology · 2016Article
- Targeting of microbubbles: contrast agents for ultrasound molecular imaging.Journal of drug targetingReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objective of this study was to optically verify the dynamic behaviors of adherent microbubbles in large blood vessel environments in response to a new ultrasound technique using modulated acoustic radiation force. MATERIALS AND
methodsPolydimethylsiloxane (PDMS) flow channels coated with streptavidin were used in targeted groups to mimic large blood vessels. The custom-modulated acoustic radiation force beam sequence was programmed on a Verasonics research scanner. In vitro experiments were performed by injecting a biotinylated lipid-perfluorobutane microbubble dispersion through flow channels. The dynamic response of adherent microbubbles was detected acoustically and simultaneously visualized using a video camera connected to a microscope. In vivo verification was performed in a large abdominal blood vessel of a murine model for inflammation with injection of biotinylated microbubbles conjugated with P-selectin antibody.
resultsAggregates of adherent microbubbles were observed optically under the influence of acoustic radiation force. Large microbubble aggregates were observed solely in control groups without targeted adhesion. Additionally, the dispersion of microbubble aggregates were demonstrated to lead to a transient acoustic signal enhancement in control groups (a new phenomenon we refer to as "control peak"). In agreement with in vitro results, the control peak phenomenon was observed in vivo in a murine model.
conclusionsThis study provides the first optical observation of microbubble-binding dynamics in large blood vessel environments with application of a modulated acoustic radiation force beam sequence. With targeted adhesion, secondary radiation forces were unable to produce large aggregates of adherent microbubbles. Additionally, the new phenomenon called control peak was observed both in vitro and in vivo in a murine model for the first time. The findings in this study provide us with a better understanding of microbubble behaviors in large blood vessel environments with application of acoustic radiation force and could potentially guide future beam sequence designs or signal processing routines for enhanced ultrasound molecular imaging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.