ArticlePloS one2015
Metabolic Effects of Access to Sucrose Drink in Female Rats and Transmission of Some Effects to Their Offspring.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Sirtuin signalling governs calcium homeostasis and mitochondrial function in metabolic syndrome cardiomyocytes.Experimental physiology · 2026Article
- AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models.Translational psychiatry · 2023Article
- Maternal fructose boosts the effects of a Western-type diet increasing SARS-COV-2 cell entry factors in male offspring.Journal of functional foods · 2023Article
- Parental overnutrition by carbohydrates in developmental origins of metabolic syndrome.Physiological research · 2021Review
- Pregnancy Is Enough to Provoke Deleterious Effects in Descendants of Fructose-Fed Mothers and Their Fetuses.Nutrients · 2021Article
- The Effects of Exercise and Restriction of Sugar-Sweetened Beverages on Muscle Function and Autophagy Regulation in High-Fat High-Sucrose-Fed Obesity Mice.Diabetes & metabolism journal · 2021Article
- Maternal High-Sucrose Diet Affects Phenotype Outcome in Adult Male Offspring: Role ofFrontiers in genetics · 2020Article
- Source of dietary sucrose influences development of leptin resistance in male and female rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Sugar Addiction: From Evolution to Revolution.Frontiers in psychiatry · 2018Review
- Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS-55) on adiposity and hepatic lipid composition in rat offspring.The Journal of physiology · 2017Article
- High-sucrose-induced maternal obesity disrupts ovarian function and decreases fertility in Drosophila melanogaster.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Metabolic consequences of flavonoid and saponin extracts fromInternational journal of health sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of this study were, first, to examine the metabolic consequences for female rats of having unrestricted access to 10% sucrose solution and, second, to test for effects of this dietary intervention on their offspring. In Stage 1 females were mated following a 4-week period in which one group was given the sucrose in addition to their normal chow and a control group was given chow and water only. Sucrose was removed at parturition and the pups monitored until weaning. Despite the development of glucose intolerance in sucrose-fed mothers, no effects were detected on litter size or pup weights. In Stage 2 voluntary activity of offspring was assessed over postnatal days (PND) 51-60 and their glucose tolerance measured at PND89-94. Again no effect of maternal diet was detected. Only male offspring were used in Stage 3, which began when they were 13 weeks old. Four groups were given 10% sucrose solution for 48 days in a 2 x 2 design, in which one factor was maternal diet and the other was whether they were given 2-h access to an activity wheel on alternate days. Higher fasting glucose levels were found in offspring of sugar-fed mothers. Exercise increased insulin sensitivity in these rats but not in offspring of control mothers. Behavioural measures of memory in Stage 3 did not reveal any effects of maternal diet or exercise. Overall, this study suggested that, while providing 10% sucrose solution ad-libitum was sufficient to impair maternal metabolism, the impact of this dietary manipulation on offspring may be revealed only when the offspring's diet is similarly manipulated.
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