ArticleThe Journal of investigative dermatology2015
Photoactivation of ROS Production In Situ Transiently Activates Cell Proliferation in Mouse Skin and in the Hair Follicle Stem Cell Niche Promoting Hair Growth and Wound Healing.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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Who cites it
44 citing papers in PubMed, 89 citations in OpenAlex.
- Emerging uses of 5-aminolevulinic-acid-induced protoporphyrin IX in medicine: a review of multifaceted, ubiquitous, molecular diagnostic, therapeutic, and theranostic opportunities.Journal of biomedical optics · 2025Review
- Aqueous Dispersion of Unmodified Fullerene C60: Stimulation of Hair Growth and Study of a New Molecular Target for Interaction.International journal of molecular sciences · 2025Article
- Targeted self-assembled anti-NFκB AuNCs-aptamer nanoplatform for precise theranostics via tailored follicle regeneration.Materials today. Bio · 2025Article
- Immune and Non-immune Interactions in the Pathogenesis of Androgenetic Alopecia.Clinical reviews in allergy & immunology · 2025Review
- The Potential Application of Nanocarriers in Delivering Topical Antioxidants.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies.Frontiers in cell and developmental biology · 2025Review
- Article
- The structural characterization and UV-protective properties of an exopolysaccharide from aFrontiers in pharmacology · 2024Article
- Potential application of PBM use in hair follicle organoid culture for the treatment of androgenic alopecia.Materials today. Bio · 2023Review
- Overview of the Circadian Clock in the Hair Follicle Cycle.Biomolecules · 2023Review
- Extracts ofAntioxidants (Basel, Switzerland) · 2023Article
- Emerging roles of mitochondria in animal regeneration.Cell regeneration (London, England) · 2023Review
- Innovative Strategies for Hair Regrowth and Skin Visualization.Pharmaceutics · 2023Review
- Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice.Inflammation and regeneration · 2023Article
- Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness.eLife · 2022Article
- Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment.Inflammation and regeneration · 2022Review
- [Effects of low-dose photodynamic therapy on the function of human adipose mesenchymal stem cells and its mechanism].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- The photosensitizer-based therapies enhance the repairing of skin wounds.Frontiers in medicine · 2022Review
- Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization.Oxidative medicine and cellular longevity · 2022Article
- The deleterious effects induced by an acute exposure of human skin to common air pollutants are prevented by extracts of Deschampsia antarctica.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The role of reactive oxygen species (ROS) in the regulation of hair follicle (HF) cycle and skin homeostasis is poorly characterized. ROS have been traditionally linked to human disease and aging, but recent findings suggest that they can also have beneficial physiological functions in vivo in mammals. To test this hypothesis, we transiently switched on in situ ROS production in mouse skin. This process activated cell proliferation in the tissue and, interestingly, in the bulge region of the HF, a major reservoir of epidermal stem cells, promoting hair growth, as well as stimulating tissue repair after severe burn injury. We further show that these effects were associated with a transient Src kinase phosphorylation at Tyr416 and with a strong transcriptional activation of the prolactin family 2 subfamily c of growth factors. Our results point to potentially relevant modes of skin homeostasis regulation and demonstrate that a local and transient ROS production can regulate stem cell and tissue function in the whole organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.