Evidence map›Paper›PMID 26134944›Full record

ArticleThe Journal of investigative dermatology2015

Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma.

Anupam Mitra, Jesus I Luna, Alina I Marusina, Alexander Merleev, Smriti Kundu-Raychaudhuri, David Fiorentino, Siba P Raychaudhuri, Emanual Maverakis

Abstract readLetter
In one paragraph

Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Redox Pathogenesis in Rheumatic Diseases.ACR open rheumatology · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. The Role of mTOR and eIF Signaling in Benign Endometrial Diseases.International journal of molecular sciences · 2022
    Review
  14. Role of PI3K/Akt signaling pathway in cardiac fibrosis.Molecular and cellular biochemistry · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Mouse tail models of secondary lymphedema: fibrosis gradually worsens and is irreversible.International journal of clinical and experimental pathology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anupam MitraDepartment of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA.
Jesus I LunaDepartment of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA.
Alina I MarusinaDepartment of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA.
Alexander MerleevDepartment of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA.
Smriti Kundu-RaychaudhuriSchool of Medicine, University of California Davis, VA Medical Center Sacramento, Mather, California, USA.
David FiorentinoDepartment of Dermatology, Stanford University, Redwood City, California, USA.
Siba P RaychaudhuriSchool of Medicine, University of California Davis, VA Medical Center Sacramento, Mather, California, USA.
Emanual MaverakisDepartment of Dermatology, School of Medicine, University of California Davis, Sacramento, California, USA. Electronic address: emaverakis@yahoo.com.

Funding

Investigation and Development of New Therapeutic Avenues for SclerodermaDP2OD008752 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MAVERAKIS, EMANUAL M. · 2011 to 2016
$2.8M
Howard Hughes Medical InstituteNIH HHS 1DP2OD008752-01NIH HHS DP2 OD008752
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiomarkersBiopsy, NeedleCells, CulturedFibroblastsFibrosisHumansImidazolesImmunohistochemistryMolecular Targeted TherapyPhosphorylationPolymerase Chain ReactionScleroderma, DiffuseSensitivity and SpecificitySirolimusSmad2 ProteinTOR Serine-Threonine KinasesBiomarkersImidazolesMTOR protein, humanOSI 027SirolimusSmad2 ProteinTOR Serine-Threonine KinasesTransforming Growth Factor betaTriazines

Identifiers

PMID26134944
PMCPMC4640976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.