Evidence map›Paper›PMID 26134827›Full record

ArticlePloS one2015

Assessment of Allergy to Milk, Egg, Cod, and Wheat in Swedish Schoolchildren: A Population Based Cohort Study.

Anna Winberg, Christina E West, Åsa Strinnholm, Lisbeth Nordström, Linnea Hedman, Eva Rönmark

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  4. Maternal dietary inflammatory index during pregnancy and the risk of offspring allergic disease.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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  10. Associations between pre- and postnatal antibiotic exposures and early allergic outcomes: A population-based birth cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anna WinbergDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Christina E WestDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Åsa StrinnholmDepartment of Public Health and Clinical Medicine, Occupational and Environmental Medicine, the OLIN unit, Umeå University, Umeå, Sweden.
Lisbeth NordströmDepartment of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Linnea HedmanDepartment of Public Health and Clinical Medicine, Occupational and Environmental Medicine, the OLIN unit, Umeå University, Umeå, Sweden.
Eva RönmarkDepartment of Public Health and Clinical Medicine, Occupational and Environmental Medicine, the OLIN unit, Umeå University, Umeå, Sweden.
Umeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesKnowledge about the prevalence of allergies to foods in childhood and adolescence is incomplete. The purpose of this study was to investigate the prevalence of allergies to milk, egg, cod, and wheat using reported data, clinical examinations, and double-blind placebo-controlled food challenges, and to describe the phenotypes of reported food hypersensitivity in a cohort of Swedish schoolchildren.

methodsIn a population-based cohort of 12-year-old children, the parents of 2612 (96% of invited) completed a questionnaire. Specific IgE antibodies to foods were analyzed in a random sample (n=695). Children reporting complete avoidance of milk, egg, cod, or wheat due to perceived hypersensitivity and without physician-diagnosed celiac disease were invited to undergo clinical examination that included specific IgE testing, a celiac screening test, and categorization into phenotypes of food hypersensitivity according to preset criteria. Children with possible food allergy were further evaluated with double-blind challenges.

resultsIn this cohort, the prevalence of reported food allergy to milk, egg, cod, or wheat was 4.8%. Food allergy was diagnosed in 1.4% of the children after clinical evaluation and in 0.6% following double-blind placebo-controlled food challenge. After clinical examination, children who completely avoided one or more essential foods due to perceived food hypersensitivity were categorized with the following phenotypes: allergy (29%), outgrown allergy (19%), lactose intolerance (40%), and unclear (12%).

conclusionsThere was a high discrepancy in the prevalence of allergy to milk, egg, cod and wheat as assessed by reported data, clinical evaluation, and double-blind food challenges. Food hypersensitivity phenotyping according to preset criteria was helpful for identifying children with food allergy.

Indexed as

AllergensAnimalsChildCohort StudiesDouble-Blind MethodEgg HypersensitivityFemaleFish ProductsFood HypersensitivityGadus morhuaHumansHypersensitivityImmunoglobulin ELactose IntoleranceMaleMilk HypersensitivityAllergensImmunoglobulin E

Identifiers

PMID26134827
PMCPMC4489866
OpenAlexW837485312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.