Evidence map›Paper›PMID 26134762›Full record

SynthesisMedical science monitor : international medical journal of experimental and clinical research2015

Survival after Gastrectomy in Node-Negative Gastric Cancer: A Review and Meta-Analysis of Prognostic Factors.

Yanming Zhou, Feng Yu, Lupeng Wu, Feng Ye, Leilei Zhang, Yumin Li

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06105515 (Laparoscopic and Endoscopic Collaborative Surgery as Rescue-treatment for Advanced Gastric Cancer in Patients Unfit for Surgery - the LE-RACUS Pilot Clinical Study), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06105515 narecruitingnot on this mapstarted 2024, after this paper: background citation

Laparoscopic and Endoscopic Collaborative Surgery as Rescue-treatment for Advanced Gastric Cancer in Patients Unfit for Surgery - the LE-RACUS Pilot Clinical Study

TypeinterventionalSponsorRegion StockholmRan2024 to 2027Enrolled20ConditionsGastric CancerArmsLaparoscopic and Endoscopic Collaborative Surgery (LECS)
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Implications of clinical research on adjuvant chemotherapy for gastric cancer: Where to go next?Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019
    Article
  8. Expression of gremlin1 in gastric cancer and its clinical significance.Medical oncology (Northwood, London, England) · 2018
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanming ZhouDepartment of Hepato-Biliary-Pancreato-Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China (mainland).
Feng YuDepartment of Hepatobiliary Surgery, The 101th Hospital of Chinese PLA, Wuxi, Jiangsu, China (mainland).
Lupeng WuDepartment of Hepato-Biliary-Pancreato-Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China (mainland).
Feng YeDepartment of Hepato-Biliary-Pancreato-Vascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China (mainland).
Leilei ZhangDepartment of Anaesthesiology, Second Hospital of Jilin University, Changchun, Jilin, China (mainland).
Yumin LiDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu, China (mainland).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymph node metastasis is one of the most important prognostic factors for survival of patients with gastric cancer (GC) after surgical resection. Nevertheless, a considerable number of patients have node-negative disease. We performed the present systematic review to evaluate survival and identify prognostic factors in node-negative GC patients undergoing curative intent resection. MATERIAL AND

methodsRelevant studies published between January 2000 and January 2015 were identified by searching the PubMed database and reviewed systematically. Summary relative risks (RR) and 95% confidence intervals (95% CI) were estimated using random-effects models.

resultsThirty observational studies involving 12 504 patients were included in the review. Median 5-year overall survival was 84.3% (range, 53-96.3%). Pooled analysis showed that old age (RR, 1.26; 95%CI, 1.13-1.42), <D2 lymph node dissection (1.28; 1.05-1.55), larger tumor (1.18; 1.10-1.26), serosal invasion (2.03; 1.68-2.44), lymphatic invasion (1.25; 1.00-1.57), vascular invasion (1.67; 1.19-2.34), and lymphovascular invasion (1.93; 1.20-3.10) were significant association with decreased survival.

conclusionsSurgical resection offers good overall survival for patients with node-negative GC. Tumor-related factors seem to have most prognostic significance.

Indexed as

GastrectomySurvival RateAgedFemaleHumansLymph NodesMaleMiddle AgedPrognosisStomach Neoplasms

Identifiers

PMID26134762
PMCPMC4500595

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.