ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015
Quantitative comparison of the microscopic anatomy of the human ACL femoral and tibial entheses.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Size and Shape of the Human Anterior Cruciate Ligament and the Impact of Sex and Skeletal Growth: A Systematic Review.JBJS reviews · 2019Pooled it
- Effect of Internal Tibial Torque on ACL Tear at the Femoral Enthesis.Annals of biomedical engineering · 2026Article
- Interobserver variability in assessing anterior cruciate ligament anatomy: comparing gross and microanatomical observations.Surgical and radiologic anatomy : SRA · 2026Article
- Collagen-elastin microstructural network and its mechanical implications in the anterior cruciate ligament: A feasibility study.Journal of orthopaedic surgery and research · 2026Article
- Article
- Dynamic Deformation Behavior of the Porcine Anterior Cruciate Ligament Enthesis Under Anterior Tibial Loading.Annals of biomedical engineering · 2025Article
- Mineralized tissue loss at the femoral ACL enthesis in young male ACL-injured patients.Journal of experimental orthopaedics · 2025Article
- Decoding the mechanical characteristics of the human anterior cruciate ligament entheses through graduated mineralization interfaces.Nature communications · 2024Article
- Anatomical Tissue Engineering of the Anterior Cruciate Ligament Entheses.International journal of molecular sciences · 2023Review
- Fatigue-driven compliance increase and collagen unravelling in mechanically tested anterior cruciate ligament.Communications biology · 2023Article
- State of the mineralized tissue comprising the femoral ACL enthesis in young women with an ACL failure.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Relationship between altered knee kinematics and subchondral bone remodeling in a clinically translational model of ACL injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Anatomy and histomorphology of the flexor digitorum profundus enthesis: functional implications for tissue engineering and surgery.BMC musculoskeletal disorders · 2021Article
- Histomorphology of the Subregions of the Scapholunate Interosseous Ligament and Its Enthesis.Journal of wrist surgery · 2021Article
- [The killer turn in the posterior cruciate ligament reconstruction: mechanism and improvement].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2020Review
- Morphology of Mouse Anterior Cruciate Ligament-Complex Changes Following Exercise During Pubertal Growth.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- An Anterior Cruciate Ligament Failure Mechanism.The American journal of sports medicine · 2019Article
- Femoral entheseal shape and attachment angle as potential risk factors for anterior cruciate ligament injury.Journal of the mechanical behavior of biomedical materials · 2018Article
- Permanent knee sensorimotor system changes following ACL injury and surgery.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2017Article
- The Challenge in Using Mesenchymal Stromal Cells for Recellularization of Decellularized Cartilage.Stem cell reviews and reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The femoral enthesis of the human anterior cruciate ligament (ACL) is known to be more susceptible to injury than the tibial enthesis. To determine whether anatomic differences might help explain this difference, we quantified the microscopic appearance of both entheses in 15 unembalmed knee specimens using light microscopy, toluidine blue stain and image analysis. The amount of calcified fibrocartilage and uncalcified fibrocartilage, and the ligament entheseal attachment angle were then compared between the femoral and tibial entheses via linear mixed-effects models. The results showed marked differences in anatomy between the two entheses. The femoral enthesis exhibited a 3.9-fold more acute ligament attachment angle than the tibial enthesis (p<0.001), a 43% greater calcified fibrocartilage tissue area (p<0.001), and a 226% greater uncalcified fibrocartilage depth (p<0.001), with the latter differences being particularly pronounced in the central region. We conclude that the ACL femoral enthesis has more fibrocartilage and a more acute ligament attachment angle than the tibial enthesis, which provides insight into why it is more vulnerable to failure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.