ArticleScientific reports2015
Detoxification mechanisms of honey bees (Apis mellifera) resulting in tolerance of dietary nicotine.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 223 citations in OpenAlex.
- Protective effects of rosmarinic acid against carbaryl-exposed toxicity in honey bees (Apis mellifera): histopathological and molecular docking evidence.Veterinary research communications · 2026Article
- Structural and Functional Insights into a Honey Bee Omega-Class Glutathione S-Transferase Mediating Chemical Sequestration and Antioxidative Stress.Journal of agricultural and food chemistry · 2026Article
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- Sulfoxaflor reduces food intake and learning efficiency of solitary Osmia bicornis bees.Scientific reports · 2026Article
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- Susceptibility to the Neonicotinoid Pesticide Imidacloprid Is Linked to Life History Regulation in Honey Bees (Apis mellifera L.).Molecular ecology · 2026Article
- Insecticide exposure alters feeding and impairs ovary development in a solitary bee.Ecotoxicology (London, England) · 2026Article
- Assessing the safety of two organosulfur compounds derived from onion in western honey bee (Apis mellifera).Scientific reports · 2026Article
- Forage quality shapes physiological and gut microbial responses in moose (Alces alces) of Isle Royale National Park.Scientific reports · 2026Article
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- Secondary Compounds in Milkweed Nectar Negatively Impact Thermal Tolerance in Bumble Bees.Ecology and evolution · 2025Article
- The Sublethal Effects of Neonicotinoids on Honeybees.Biology · 2025Review
- Chronic Larval Exposure to Lambda-Cyhalothrin Alters Gene Expression in Both Larval and Adult Honey Bees (Insects · 2025Article
- The Efficiency of the Krebs Cycle and the Respiratory Chain in Physiologically and Prematurely Aging Bees (International journal of molecular sciences · 2025Article
- A risk based pollination network for non-Apis bees demonstrates the importance of understory plant contamination.Scientific reports · 2025Article
- Honey bee immune response to trace concentrations of clothianidin goes beyond the macronutrients found in artificial diets.Scientific reports · 2025Article
- An Overview of the Adverse Impacts of Old Combs on Honeybee Colonies and Recommended Beekeeping Management Strategies.Insects · 2025Review
- Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management.Natural products and bioprospecting · 2025Article
- Comparative Proteomics of Resistant and Susceptible Strains of Frankliniella occidentalis to Abamectin.Electrophoresis · 2025Article
- Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Insecticides are thought to be among the major factors contributing to current declines in bee populations. However, detoxification mechanisms in healthy, unstressed honey bees are poorly characterised. Alkaloids are naturally encountered in pollen and nectar, and we used nicotine as a model compound to identify the mechanisms involved in detoxification processes in honey bees. Nicotine and neonicotinoids have similar modes of action in insects. Our metabolomic and proteomic analyses show active detoxification of nicotine in bees, associated with increased energetic investment and also antioxidant and heat shock responses. The increased energetic investment is significant in view of the interactions of pesticides with diseases such as Nosema spp which cause energetic stress and possible malnutrition. Understanding how healthy honey bees process dietary toxins under unstressed conditions will help clarify how pesticides, alone or in synergy with other stress factors, lead to declines in bee vitality.
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Registered trials
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