ArticleBMC complementary and alternative medicine2015
Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (Açaí) in a rodent model of acute and neuropathic pain.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Anticancer potential, molecular mechanisms and toxicity of Euterpe oleracea extract (açaí): A systematic review.PloS one · 2018Pooled it
- Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects ofPlants (Basel, Switzerland) · 2025Review
- Euterpe oleracea extract (açaí) exhibits cardioprotective effects after chemotherapy treatment in a breast cancer model.BMC complementary medicine and therapies · 2023Article
- Açaí (Nutrients · 2023Review
- A validated Folin-Ciocalteu method for total phenolics quantification of condensed tannin-rich açaí (Journal of food science and technology · 2021Article
- Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514.Molecules (Basel, Switzerland) · 2021Article
- Euterpe oleracea Mart. (Açaí) attenuates experimental colitis in rats: involvement of TLR4/COX-2/NF-ĸB.Inflammopharmacology · 2021Article
- Myorelaxation, respiratory depression and electrocardiographic changes caused by the administration of extract of açai (Toxicology reports · 2021Article
- Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food.Antioxidants (Basel, Switzerland) · 2020Article
- The Use ofBiomolecules · 2020Review
- The value of the Brazilian açai fruit as a therapeutic nutritional strategy for chronic kidney disease patients.International urology and nephrology · 2018Review
- Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer.BMC complementary and alternative medicine · 2018Article
- Analgesic effects of Marasmius androsaceus mycelia ethanol extract and possible mechanisms in mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Novel agonist of αJournal of pain research · 2018Article
- Chemical Composition and Antioxidant Activity of Euterpe oleracea Roots and Leaflets.International journal of molecular sciences · 2016Article
- Euterpe oleracea Extract (Açaí) Is a Promising Novel Pharmacological Therapeutic Treatment for Experimental Endometriosis.PloS one · 2016Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlants rich in flavonoids, such as açaí (Euterpe oleraceae Mart.), can induce antinociception in experimental animals. Here, we tested an extract obtained from the stones of açaí fruits (açaí stone extract, ASE), a native plant from the Amazon region of Brazil, in models of acute/inflammatory and chronic pain.
methodsAntinociceptive effects of ASE were evaluated in the hot plate, formalin, acetic acid writhing, carrageenan, and neuropathic pain models, as well as in thermal hyperalgesia and mechanical allodynia models induced by spinal nerve ligation. Antinociceptive activities were modulated by the administration of cholinergic, adrenergic, opioid, and L-arginine-NO antagonists.
resultsOral administration of ASE (30, 100, or 300 mg.kg(-1)) dose-dependently reduced nociceptive responses to acute/inflammatory pain in mice, including thermal hyperalgesia, acetic acid-induced writhing, and carrageenan-induced thermal hyperalgesia. Moreover, ASE reduced the neurogenic and inflammatory phases after intraplantar injection of formalin in mice. The antinociceptive effect of ASE (100 mg · kg(-1)) in a hot plate protocol, was inhibited by pre-treatment with naloxone (1 mg · kg(-1)), atropine (2 mg · kg(-1)), yohimbine (5 mg · kg(-1)), or L-NAME (30 mg · kg(-1)). Furthermore, ASE prevented chronic pain in a rat spinal nerve ligation model, including thermal hyperalgesia and mechanical allodynia.
conclusionASE showed significant antinociceptive effect via a multifactorial mechanism of action, indicating that the extract may be useful in the development of new analgesic drugs.
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