ArticleMolecular systems biology2015
Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing.
Article in Molecular systems biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents.Cell proliferation · 2026Article
- Alternative splicing contributes to plasticity and regulatory divergence in locally adapted house mice from the Americas.Molecular biology and evolution · 2026Article
- Branch point strength controls species-specificLife science alliance · 2023Article
- Alternative splicing as a source of phenotypic diversity.Nature reviews. Genetics · 2022Review
- DeeReCT-APA: Prediction of Alternative Polyadenylation Site Usage Through Deep Learning.Genomics, proteomics & bioinformatics · 2022Article
- Mammalian splicing divergence is shaped by drift, buffering inLife science alliance · 2022Article
- Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change.Nature communications · 2022Article
- Alternative splicing and gene expression play contrasting roles in the parallel phenotypic evolution of a salmonid fish.Molecular ecology · 2021Article
- Molecular and evolutionary processes generating variation in gene expression.Nature reviews. Genetics · 2021Review
- Transcriptome-Wide Analyses Identify Dominant as the Predominantly Non-Conservative Alternative Splicing Inheritance Patterns in F1 Chickens.Frontiers in genetics · 2021Article
- Systematic Analysis of Monoallelic Gene Expression and Chromatin Accessibility Across Multiple Tissues in Hybrid Mice.Frontiers in cell and developmental biology · 2021Article
- Cis-regulatory differences in isoform expression associate with life history strategy variation in Atlantic salmon.PLoS genetics · 2020Article
- Maternal effects shape the alternative splicing of parental alleles in reciprocal cross hybrids of Megalobrama amblycephala × Culter alburnus.BMC genomics · 2020Article
- Alternative Splicing by NOVA Factors: From Gene Expression to Cell Physiology and Pathology.International journal of molecular sciences · 2020Review
- Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation.Molecular systems biology · 2020Article
- The Legacy of Sexual Ancestors in Phenotypic Variability, Gene Expression, and Homoeolog Regulation of Asexual Hybrids and Polyploids.Molecular biology and evolution · 2019Article
- Allele-specific expression and alternative splicing in horse×donkey and cattle×yak hybrids.Zoological research · 2019Article
- Pervasive allele-specific regulation on RNA decay in hybrid mice.Life science alliance · 2018Article
- Characterization of cis-acting elements that control oscillating alternative splicing.RNA biology · 2018Article
- Alternative Splicing: Expanding Diversity in Major ABC and SLC Drug Transporters.The AAPS journal · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Divergence of alternative splicing represents one of the major driving forces to shape phenotypic diversity during evolution. However, the extent to which these divergences could be explained by the evolving cis-regulatory versus trans-acting factors remains unresolved. To globally investigate the relative contributions of the two factors for the first time in mammals, we measured splicing difference between C57BL/6J and SPRET/EiJ mouse strains and allele-specific splicing pattern in their F1 hybrid. Out of 11,818 alternative splicing events expressed in the cultured fibroblast cells, we identified 796 with significant difference between the parental strains. After integrating allele-specific data from F1 hybrid, we demonstrated that these events could be predominately attributed to cis-regulatory variants, including those residing at and beyond canonical splicing sites. Contrary to previous observations in Drosophila, such predominant contribution was consistently observed across different types of alternative splicing. Further analysis of liver tissues from the same mouse strains and reanalysis of published datasets on other strains showed similar trends, implying in general the predominant contribution of cis-regulatory changes in the evolution of mouse alternative splicing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.