ArticleDiagnostic pathology2015
Effect of platelet-rich plasma on the healing of cutaneous defects exposed to acute to chronic wounds: a clinico-histopathologic study in rabbits.
Article in Diagnostic pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Platelet-rich plasma to treat experimentally-induced skin wounds in animals: A systematic review and meta-analysis.PloS one · 2018Pooled it
- The Clinical Efficacy of Autologous Platelet-Rich Plasma Combined with Ultra-Pulsed Fractional CORejuvenation research · 2017Trial
- Current Trends on Innovative Technologies in Topical Wound Care for Advanced Healing and Management.Current drug research reviews · 2024Review
- Platelet-rich plasma: a comparative and economical therapy for wound healing and tissue regeneration.Cell and tissue banking · 2023Review
- Healing effect of acellular fish skin with plasma rich in growth factor on full-thickness skin defects.International wound journal · 2022Article
- Wound healing effects and antibacterial properties of heterologous platelet-rich plasma onJournal of advanced veterinary and animal research · 2022Article
- Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements.Cells · 2022Review
- Article
- Incidence of Patellar Desmopathy in the Modified Maquet Technique with and without PRGF.Veterinary sciences · 2022Article
- Role of platelet rich plasma mediated repair and regeneration of cell in early stage of cardiac injury.Regenerative therapy · 2022Review
- Role of MSC-derived small extracellular vesicles in tissue repair and regeneration.Frontiers in cell and developmental biology · 2022Review
- Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits.Acta cirurgica brasileira · 2020Article
- Use of platelet-rich plasma to facilitate wound healing.International wound journal · 2019Article
- Evaluate the effects of platelet rich plasma (PRP) and zinc oxide ointment on skin wound healing.Annals of medicine and surgery (2012) · 2019Article
- Combined plasma rich in growth factors and adipose-derived mesenchymal stem cells promotes the cutaneous wound healing in rabbits.BMC veterinary research · 2018Article
- The effectiveness of platelet-rich plasma on the skin wound healing process: A comparative experimental study in sheep.Veterinary world · 2018Article
- Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management.Journal of functional biomaterials · 2018Review
- Fractal features of rabbit dermal wounds treated with platelet-rich plasma and topical rosuvastatin.International journal of clinical and experimental pathology · 2018Article
- An overview of platelet products (PRP, PRGF, PRF, etc.) in the Iranian studies.Future science OA · 2017Review
- Retraction note: Effect of platelet-rich plasma on the healing of cutaneous defects exposed to acute to chronic wounds: a clinico-histopathologic study in rabbits.Diagnostic pathology · 2016Article
Corrections and comments
- Retraction · 2016-11-02Concerns/Issues about Authorship/Affiliation · Compromised Peer Review · False/Forged Authorship · Investigation by Journal/Publisher · Misconduct by Author · Plagiarism of Text · · Author AKA Koroosh Ahmadi (same email: ahmadik@mums.ac.ir)
- Retracted
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet-rich plasma (PRP) contains numerous growth factors to promote wound healing and angiogenesis. The aim of this study was to gain further information about the benefits of platelet-rich-plasma for healing cutaneous acute to chronic wounds.
methodsA total of 30 New Zealand albino rabbits (n = 15/group) were randomly assigned to two experimental groups: control group, and PRP group. Bilateral resection defects measuring 3 cm were surgically created on the dorsolateral of the cutaneous in animals and the defects were randomly divided into two mentioned groups. Wound area, neovascularization, size and epithelialization were compared on days 7, 14 and 21 post-wounding. Histopathological analyses were conducted on 15 specimens from each group after sacrifice by the cellular aspects of the regeneration of the tissue.
resultsOur results were indicated that the wound area of PRP was smaller than that in the non-treated group on days 7, 14 and 21. Furthermore, a significant decrease of the wound size was observed in PRP groups that were significantly greater than that in the control group. A significant increase of the mean vascular density was noted in the PRP treated groups compared to the control groups at day 14 and especially day 21. This results indicated that PRP treated group' enhanced angiogenesis at the wound beds as compared to no treatment group.
conclusionThese results could be useful for researchers in the growing fields of tissue repair and experimental wound healing. Further studies will be essential to determine the role of PRP in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.