Evidence map›Paper›PMID 26134341›Full record

ArticleAmerican journal of critical care : an official publication, American Association of Critical-Care Nurses2015

Cerebral Perfusion Pressure and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.

Khalil M Yousef, Jeffrey R Balzer, Catherine M Bender, Leslie A Hoffman, Samuel M Poloyac, Feifei Ye, Paula R Sherwood

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Vasopressor Infusion After Subarachnoid Hemorrhage Does Not Increase Regional Cerebral Tissue Oxygenation.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Khalil M YousefKhalil M. Yousef is an assistant professor, Department of Clinical Nursing, School of Nursing, University of Jordan, Amman, Jordan. Jeffrey R. Balzer is an associate professor of neurological surgery in the School of Nursing, University of Pittsburgh, and the Department of Neurosurgery and Neuroscience, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Catherine M. Bender is a professor and Leslie A. Hoffman is a professor emeritus, School of Nursing, Samuel M. Poloyac is a professor, School of Pharmacy, Feifei Ye is an assistant professor, School of Education, and Paula R. Sherwood is a professor in the School of Nursing and the School of Medicine, University of Pittsburgh. K.yousef@ju.edu.jo.
Jeffrey R BalzerKhalil M. Yousef is an assistant professor, Department of Clinical Nursing, School of Nursing, University of Jordan, Amman, Jordan. Jeffrey R. Balzer is an associate professor of neurological surgery in the School of Nursing, University of Pittsburgh, and the Department of Neurosurgery and Neuroscience, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Catherine M. Bender is a professor and Leslie A. Hoffman is a professor emeritus, School of Nursing, Samuel M. Poloyac is a professor, School of Pharmacy, Feifei Ye is an assistant professor, School of Education, and Paula R. Sherwood is a professor in the School of Nursing and the School of Medicine, University of Pittsburgh.
Catherine M BenderKhalil M. Yousef is an assistant professor, Department of Clinical Nursing, School of Nursing, University of Jordan, Amman, Jordan. Jeffrey R. Balzer is an associate professor of neurological surgery in the School of Nursing, University of Pittsburgh, and the Department of Neurosurgery and Neuroscience, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Catherine M. Bender is a professor and Leslie A. Hoffman is a professor emeritus, School of Nursing, Samuel M. Poloyac is a professor, School of Pharmacy, Feifei Ye is an assistant professor, School of Education, and Paula R. Sherwood is a professor in the School of Nursing and the School of Medicine, University of Pittsburgh.
Leslie A HoffmanKhalil M. Yousef is an assistant professor, Department of Clinical Nursing, School of Nursing, University of Jordan, Amman, Jordan. Jeffrey R. Balzer is an associate professor of neurological surgery in the School of Nursing, University of Pittsburgh, and the Department of Neurosurgery and Neuroscience, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Catherine M. Bender is a professor and Leslie A. Hoffman is a professor emeritus, School of Nursing, Samuel M. Poloyac is a professor, School of Pharmacy, Feifei Ye is an assistant professor, School of Education, and Paula R. Sherwood is a professor in the School of Nursing and the School of Medicine, University of Pittsburgh.
Samuel M PoloyacKhalil M. Yousef is an assistant professor, Department of Clinical Nursing, School of Nursing, University of Jordan, Amman, Jordan. Jeffrey R. Balzer is an associate professor of neurological surgery in the School of Nursing, University of Pittsburgh, and the Department of Neurosurgery and Neuroscience, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Catherine M. Bender is a professor and Leslie A. Hoffman is a professor emeritus, School of Nursing, Samuel M. Poloyac is a professor, School of Pharmacy, Feifei Ye is an assistant professor, School of Education, and Paula R. Sherwood is a professor in the School of Nursing and the School of Medicine, University of Pittsburgh.
Feifei YeKhalil M. Yousef is an assistant professor, Department of Clinical Nursing, School of Nursing, University of Jordan, Amman, Jordan. Jeffrey R. Balzer is an associate professor of neurological surgery in the School of Nursing, University of Pittsburgh, and the Department of Neurosurgery and Neuroscience, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Catherine M. Bender is a professor and Leslie A. Hoffman is a professor emeritus, School of Nursing, Samuel M. Poloyac is a professor, School of Pharmacy, Feifei Ye is an assistant professor, School of Education, and Paula R. Sherwood is a professor in the School of Nursing and the School of Medicine, University of Pittsburgh.
Paula R SherwoodKhalil M. Yousef is an assistant professor, Department of Clinical Nursing, School of Nursing, University of Jordan, Amman, Jordan. Jeffrey R. Balzer is an associate professor of neurological surgery in the School of Nursing, University of Pittsburgh, and the Department of Neurosurgery and Neuroscience, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Catherine M. Bender is a professor and Leslie A. Hoffman is a professor emeritus, School of Nursing, Samuel M. Poloyac is a professor, School of Pharmacy, Feifei Ye is an assistant professor, School of Education, and Paula R. Sherwood is a professor in the School of Nursing and the School of Medicine, University of Pittsburgh.
Neurological Surgery · US

Funding

Role of 20-HETE on Vasospasm-Induced Ischemia after Subarachnoid HemorrhageR01NR004339 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLOYAC, SAMUEL M, SHERWOOD, PAULA R · 1999 to 2013
$7.2M
NINR NIH HHS R01 NR004339NINR NIH HHS R01NR004339
6 · The paper itself

Abstract

backgroundWhether delayed cerebral ischemia (DCI) mediates the relationship between Hunt and Hess grade and outcomes after aneurysmal subarachnoid hemorrhage remains unknown.

objectivesTo investigate the relationship between cerebral perfusion pressure, DCI, Hunt and Hess grade, and outcomes after aneurysmal subarachnoid hemorrhage.

methodsDCI was defined as neurological deterioration due to impaired cerebral blood flow. Relationships between minimum cerebral perfusion pressure and onset and occurrence of DCI were tested by using logistic regression and the accelerated failure time model. The mediation effect of DCI on relationships between Hunt and Hess grade and outcomes was tested by using the bootstrap confidence interval. Outcomes at 3 and 12 months included mortality and neuropsychological, functional, and physical outcomes.

resultsDCI occurred in 211 patients (42%). About one-third of the patients had poor functional outcome at 3 (32%) and 12 (30%) months. Impaired neuropsychological outcome was observed in 33% of patients at 3 months and 17% at 12 months. For every increase of 10 mm Hg in cerebral perfusion pressure, odds for DCI increased by 2.78 (95% CI, 2.00-3.87). High perfusion pressure was associated with earlier onset of DCI (P < .001).

conclusionsDCI does not mediate the relationship of Hunt and Hess grade to functional outcome or death. The relationship between cerebral perfusion pressure and DCI was most likely due to induced hypertension and hypervolemia. Clinical guidelines may need to include limits for induced hypertension.

Indexed as

AdultBrain IschemiaCerebrovascular CirculationFemaleFollow-Up StudiesHumansIntracranial AneurysmMaleMiddle AgedSubarachnoid HemorrhageYoung Adult

Identifiers

PMID26134341
PMCPMC4666532
OpenAlexW2208418502

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.