Evidence map›Paper›PMID 26134311›Full record

ArticleNanoscale2015

Dendritic nanoconjugates for intracellular delivery of neutral oligonucleotides.

Xin Ming, Lin Wu, Kyle Carver, Ahu Yuan, Yuanzeng Min

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. The Evolving Treatment of Diabetic Retinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Xin MingDivision of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. xming@email.unc.edu.
Lin Wu
Kyle Carver
Ahu Yuan
Yuanzeng Min
University of North Carolina at Chapel Hill · USClinical Research Management · USCommunities In Schools of Orange County · USNanjing University · CN

Funding

Translational Nanosystems for Improved Lung Cancer Treatment with Small MoleculesU54CA151652 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DESIMONE, JOSEPH M. · 2010 to 2014
$12.1M
Intracellular Trafficking of Antisense and siRNA Oligonucleotides in Cancer CellsR01CA151964 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JULIANO, RUDOLPH · 2011 to 2014
$1.2M
NCI NIH HHS 5R01CA151964NCI NIH HHS 5U54CA151652NCI NIH HHS R01 CA151964NCI NIH HHS U54 CA151652
6 · The paper itself

Abstract

Dendrimer-based gene delivery has been constrained by intrinsic toxicity and suboptimal nanostructure. Conjugation of neutral morpholino oligonucleotides (ONs) with PAMAM dendrimers resulted in neutral, uniform, and ultra-small (∼10 nm) nanoconjugates. The nanoconjugates dramatically enhanced cellular delivery of the ONs in cancer cells. After release from the dendrimer in the cytosol, the ONs produced potent functional activity without causing significant cytotoxicity. When carrying an apoptosis-promoting ON, the nanoconjugates produced cancer cell killing directly. Thus, the dendritic nanoconjugates may provide an effective tool for delivering ONs to tumors and other diseased tissues.

Indexed as

ApoptosisBase SequenceCell Line, TumorDendrimersEndocytosisHumansMicroscopy, ConfocalMorpholinosMyeloid Cell Leukemia Sequence 1 ProteinNanoconjugatesTransfectionDendrimersMCL1 protein, humanMorpholinosMyeloid Cell Leukemia Sequence 1 ProteinNanoconjugatesPAMAM Starburst

Identifiers

PMID26134311
PMCPMC4598944
OpenAlexW1951228267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.