ArticleScientific reports2015
Multiple scale model for cell migration in monolayers: Elastic mismatch between cells enhances motility.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Article
- Phase-field modeling of border cell cluster migration in Drosophila.PLoS computational biology · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- BIOPOINT: A particle-based model for probing nuclear mechanics and cell-ECM interactions via experimentally derived parameters.PLoS computational biology · 2026Article
- Validating the predictions of mathematical models describing tumor growth and treatment response.ArXiv · 2025Article
- Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers.Journal Of Elasticity · 2025Article
- Confinement, Jamming, and Adhesion in Cancer Cells Dissociating from a Collectively Invading Strand.PRX life · 2025Article
- Dynamic cluster field modeling of collective chemotaxis.Scientific reports · 2024Article
- Dynamics of multicellular swirling on micropatterned substrates.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Short-range correlation of stress chains near solid-to-liquid transition in active monolayers.Journal of the Royal Society, Interface · 2024Article
- Article
- Robust statistical properties of T1 transitions in a multi-phase field model of cell monolayers.Scientific reports · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- Article
- MorphoSim: an efficient and scalable phase-field framework for accurately simulating multicellular morphologies.NPJ systems biology and applications · 2023Article
- Article
- Picking winners in cell-cell collisions: Wetting, speed, and contact.Physical review. E · 2022Article
- Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers.Nature materials · 2021Article
- Computational models of migration modes improve our understanding of metastasis.APL bioengineering · 2020Review
- Reversible elastic phase field approach and application to cell monolayers.The European physical journal. E, Soft matter · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose a multiscale model for monolayer of motile cells that comprise normal and cancer cells. In the model, the two types of cells have identical properties except for their elasticity; cancer cells are softer and normal cells are stiffer. The goal is to isolate the role of elasticity mismatch on the migration potential of cancer cells in the absence of other contributions that are present in real cells. The methodology is based on a phase-field description where each cell is modeled as a highly-deformable self-propelled droplet. We simulated two types of nearly confluent monolayers. One contains a single cancer cell in a layer of normal cells and the other contains normal cells only. The simulation results demonstrate that elasticity mismatch alone is sufficient to increase the motility of the cancer cell significantly. Further, the trajectory of the cancer cell is decorated by several speed "bursts" where the cancer cell quickly relaxes from a largely deformed shape and consequently increases its translational motion. The increased motility and the amplitude and frequency of the bursts are in qualitative agreement with recent experiments.
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