ArticleGenetics2015
The Hairless Stem Phenotype of Cotton (Gossypium barbadense) Is Linked to a Copia-Like Retrotransposon Insertion in a Homeodomain-Leucine Zipper Gene (HD1).
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Genomic reconstruction of upland cotton domestication uncovers staged selection, gene flow, and flowering-time adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A Natural LTR Retrotransposon Insertion in the Promoter of GhNAC140-Dt Boosts Cotton Lint Yield.Plant biotechnology journal · 2026Article
- Graph pan-genome illuminates evolutionary trajectories and agronomic trait architecture in allotetraploid cotton.Nature genetics · 2026Article
- Genetic basis and role of exotic accessions in cultivated cotton fiber quality improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Integrative genomic structural variation analysis unveils genetic architecture underlying important traits in Gossypium barbadense.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Pangenome analysis reveals yield- and fiber-related diversity and interspecific gene flow in Gossypium barbadense L.Nature communications · 2025Article
- Transcriptomic exploration yields novel perspectives on the regulatory network underlying trichome initiation inFrontiers in plant science · 2025Article
- Article
- Large-fragment insertion activates gene GaFZ (Ga08G0121) and is associated with the fuzz and trichome reduction in cotton (Gossypium arboreum).Plant biotechnology journal · 2021Article
- Differentiation in the genetic basis of stem trichome development between cultivated tetraploid cotton species.BMC plant biology · 2021Article
- Elucidation of sequence polymorphism in fuzzless-seed cotton lines.Molecular genetics and genomics : MGG · 2021Article
- GaHD1, a candidate gene for the Gossypium arboreum SMA-4 mutant, promotes trichome and fiber initiation by cellular HPlant molecular biology · 2020Article
- Genomic Insight into Differentiation and Selection Sweeps in the Improvement of Upland Cotton.Plants (Basel, Switzerland) · 2020Article
- Article
- Genetic Identification and Transcriptome Analysis of Lintless and Fuzzless Traits inInternational journal of molecular sciences · 2020Article
- Introgression Leads to Genomic Divergence and Responsible for Important Traits in Upland Cotton.Frontiers in plant science · 2020Article
- ThePlant direct · 2019Article
- Identifying favorable alleles for improving key agronomic traits in upland cotton.BMC plant biology · 2019Article
- A D-genome-originated Ty1/Copia-type retrotransposon family expanded significantly in tetraploid cottons.Molecular genetics and genomics : MGG · 2018Article
- The Immature Fiber Mutant Phenotype of Cotton (Gossypium hirsutum) Is Linked to a 22-bp Frame-Shift Deletion in a Mitochondria Targeted Pentatricopeptide Repeat Gene.G3 (Bethesda, Md.) · 2016Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cotton (Gossypium) stem trichomes are mostly single cells that arise from stem epidermal cells. In this study, a homeodomain-leucine zipper gene (HD1) was found to cosegregate with the dominant trichome locus previously designated as T1 and mapped to chromosome 6. Characterization of HD1 orthologs revealed that the absence of stem trichomes in modern Gossypium barbadense varieties is linked to a large retrotransposon insertion in the ninth exon, 2565 bp downstream from the initial codon in the At subgenome HD1 gene (At-GbHD1). In both the At and Dt subgenomes, reduced transcription of GbHD1 genes is caused by this insertion. The disruption of At-HD1 further affects the expression of downstream GbMYB25 and GbHOX3 genes. Analyses of primitive cultivated accessions identified another retrotransposon insertion event in the sixth exon of At-GbHD1 that might predate the previously identified retrotransposon in modern varieties. Although both retrotransposon insertions results in similar phenotypic changes, the timing of these two retrotransposon insertion events fits well with our current understanding of the history of cotton speciation and dispersal. Taken together, the results of genetics mapping, gene expression and association analyses suggest that GbHD1 is an important component that controls stem trichome development and is a promising candidate gene for the T1 locus. The interspecific phenotypic difference in stem trichome traits also may be attributable to HD1 inactivation associated with retrotransposon insertion.
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