Evidence map›Paper›PMID 26133801›Full record

ArticleJournal of neurophysiology2015

Brain activity mapping at multiple scales with silicon microprobes containing 1,024 electrodes.

Justin L Shobe, Leslie D Claar, Sepideh Parhami, Konstantin I Bakhurin, Sotiris C Masmanidis

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. A Framework for Compressive On-Chip Action Potential Recording.IEEE transactions on bio-medical engineering · 2026
    Article
  5. Review
  6. Article
  7. Characterization of Auditory Responsive Neurons in the Mouse Superior Colliculus to White Noise and Frequency-Restricted Sounds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Interneuron theta phase locking controls seizure susceptibility.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. An adaptable, reusable, and light implant for chronic Neuropixels probes.bioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justin L ShobeDepartment of Neurobiology, University of California, Los Angeles, California;
Leslie D ClaarDepartment of Bioengineering, University of California, Los Angeles, California;
Sepideh ParhamiNeuroscience Interdepartmental Program, University of California, Los Angeles, California;
Konstantin I BakhurinNeuroscience Interdepartmental Program, University of California, Los Angeles, California;
Sotiris C MasmanidisDepartment of Neurobiology, University of California, Los Angeles, California; Department of Bioengineering, University of California, Los Angeles, California; Neuroscience Interdepartmental Program, University of California, Los Angeles, California; Integrative Center for Learning and Memory, University of California, Los Angeles, California; and California NanoSystems Institute, University of California, Los Angeles, California smasmanidis@ucla.edu.

Funding

Training Program in Neural MicrocircuitsT32NS058280 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2007 to 2017
$2.4M
Systems-level electrophysiology for addiction and reward researchR01DA034178 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MASMANIDIS, SOTIRIS · 2012 to 2016
$1.5M
NIDA NIH HHS R01 DA034178NIDA NIH HHS R01-DA-034178NINDS NIH HHS T32-NS058280
6 · The paper itself

Abstract

The coordinated activity of neural ensembles across multiple interconnected regions has been challenging to study in the mammalian brain with cellular resolution using conventional recording tools. For instance, neural systems regulating learned behaviors often encompass multiple distinct structures that span the brain. To address this challenge we developed a three-dimensional (3D) silicon microprobe capable of simultaneously measuring extracellular spike and local field potential activity from 1,024 electrodes. The microprobe geometry can be precisely configured during assembly to target virtually any combination of four spatially distinct neuroanatomical planes. Here we report on the operation of such a device built for high-throughput monitoring of neural signals in the orbitofrontal cortex and several nuclei in the basal ganglia. We perform analysis on systems-level dynamics and correlations during periods of conditioned behavioral responding and rest, demonstrating the technology's ability to reveal functional organization at multiple scales in parallel in the mouse brain.

Indexed as

Action PotentialsAnimalsBasal GangliaBrain MappingElectrodesElectroencephalographyFrontal LobeMiceMice, Inbred C57BLSiliconSiliconbasal gangliahigh-density electrodesmultielectrodesorbitofrontal cortexsilicon probes

Identifiers

PMID26133801
PMCPMC4583565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.