ArticlePloS one2015
Transcriptome Profiling of Tomato Fruit Development Reveals Transcription Factors Associated with Ascorbic Acid, Carotenoid and Flavonoid Biosynthesis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 108 citations in OpenAlex.
- Root-sourced 1-aminocyclopropane-1-carboxylic acid modulates development and adaptive responses to salinity in tomato.The Plant journal : for cell and molecular biology · 2026Article
- Multi-omics exploration of the involvement of ABA in identifying unique molecular markers for single and combined stresses in tomato plants.Journal of experimental botany · 2025Article
- Integrative transcriptomic and metabolomic analysis reveals the flavor formation mechanism of green bamboo (Food chemistry. Molecular sciences · 2025Article
- Comparative Transcriptome Reveals Conserved Gene Expression in Reproductive Organs in Solanaceae.International journal of molecular sciences · 2025Article
- Changes in Endogenous Carotenoids, Flavonoids, and Phenolics of Drought-Stressed Broccoli Seedlings After Ascorbic Acid Preconditioning.Plants (Basel, Switzerland) · 2024Article
- Integrated metabolome and transcriptome analysis provides clues to fruit color formation of yellow, orange, and red bell pepper.Scientific reports · 2024Article
- Genome-Wide Characterization of theInternational journal of molecular sciences · 2024Article
- Metabolite-based genome-wide association studies enable the dissection of the genetic bases of flavonoids, betaine and spermidine in wolfberry (Lycium).Plant biotechnology journal · 2024Article
- Editorial: Transcriptomics of fruit growth, development and ripening.Frontiers in plant science · 2024Article
- Transcriptomic analysis reveals the gene regulatory networks involved in leaf and root response to osmotic stress in tomato.Frontiers in plant science · 2023Article
- Effect of Light Quality on Metabolomic, Ionomic, and Transcriptomic Profiles in Tomato Fruit.International journal of molecular sciences · 2022Article
- Transcriptome and Metabolome Analysis of Color Changes during Fruit Development of Pepper (International journal of molecular sciences · 2022Article
- Putative Transcription Factor Genes Associated with Regulation of Carotenoid Biosynthesis in Chili Pepper Fruits Revealed by RNA-Seq Coexpression Analysis.International journal of molecular sciences · 2022Article
- Contrasting Roles of Ethylene Response Factors in Pathogen Response and Ripening in Fleshy Fruit.Cells · 2022Review
- Identification of essential element determining fruit-specific transcriptional activity in the tomato HISTIDINE DECARBOXYLASE A gene promoter.Plant cell reports · 2022Article
- Genome-wide characterization of the TALE homeodomain family and the KNOX-BLH interaction network in tomato.Plant molecular biology · 2022Article
- Metabolism and Regulation of Ascorbic Acid in Fruits.Plants (Basel, Switzerland) · 2022Review
- Transcriptome and carotenoid profiling of different varieties ofPlant diversity · 2022Article
- Flavonoid biosynthesis in four Dendrobium species based on transcriptome sequencing and metabolite analysis.Molecular biology reports · 2022Article
- Ascorbic Acid Content and Transcriptional Profiling of Genes Involved in Its Metabolism during Development of Petals, Leaves, and Fruits of Orange (Plants (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tomato (Solanum lycopersicum) serves as a research model for fruit development; however, while it is an important dietary source of antioxidant nutrients, the transcriptional regulation of genes that determine nutrient levels remains poorly understood. Here, the transcriptomes of fruit at seven developmental stages (7, 14, 21, 28, 35, 42 and 49 days after flowering) from two tomato cultivars (Ailsa Craig and HG6-61) were evaluated using the Illumina sequencing platform. A total of 26,397 genes, which were expressed in at least one developmental stage, were detected in the two cultivars, and the expression patterns of those genes could be divided into 20 groups using a K-mean cluster analysis. Gene Ontology term enrichment analysis indicated that genes involved in RNA regulation, secondary metabolism, hormone metabolism and cell wall metabolism were the most highly differentially expressed genes during fruit development and ripening. A co-expression analysis revealed several transcription factors whose expression patterns correlated with those of genes associated with ascorbic acid, carotenoid and flavonoid biosynthesis. This transcriptional correlation was confirmed by agroinfiltration mediated transient expression, which showed that most of the enzymatic genes in the ascorbic acid biosynthesis were regulated by the overexpression of each of the three transcription factors that were tested. The metabolic dynamics of ascorbic acid, carotenoid and flavonoid were investigated during fruit development and ripening, and some selected transcription factors showed transcriptional correlation with the accumulation of ascorbic acid, carotenoid and flavonoid. This transcriptome study provides insight into the regulatory mechanism of fruit development and presents candidate transcription factors involved in secondary metabolism.
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