Evidence map›Paper›PMID 26133659›Full record

ReviewBiochimie2016

Metabolic endotoxemia with obesity: Is it real and is it relevant?

Nabil E Boutagy, Ryan P McMillan, Madlyn I Frisard, Matthew W Hulver

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochimie, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04687709 (To Investigate the Role of Gut Microbiome in Androgen Deprivation Therapy Related Metabolic Changes in Prostate Cancer Patients), which is not on this map. Cited by 215 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 2 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04687709 completednot on this mapstarted 2021, after this paper: background citation

To Investigate the Role of Gut Microbiome in Androgen Deprivation Therapy Related Metabolic Changes in Prostate Cancer Patients

TypeobservationalSponsorChinese University of Hong KongRan2021 to 2023Enrolled50ConditionsProstate Cancer
3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 2 syntheses or guidelines pooled it, 389 citations in OpenAlex.

  1. Pooled it
  2. The Promising Ability ofMolecules (Basel, Switzerland) · 2021
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study.American journal of physiology. Endocrinology and metabolism · 2021
    Trial
  7. Lower Pretreatment Gut Integrity Is Independently Associated With Fat Gain on Antiretroviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Trial
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Implications of leaky gut in cattle.Animal frontiers : the review magazine of animal agriculture · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nabil E BoutagyThe Department of Human Nutrition, Foods, and Exercise, 295 West Campus Drive, Virginia Tech, Blacksburg, VA 24061, USA; The Fralin Translational Obesity Research Center, 1981 Kraft Drive, Virginia Tech, Blacksburg, VA 24061, USA; The Metabolic Phenotyping Core, 1981 Kraft Drive, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: nabilb@vt.edu.
Ryan P McMillanThe Department of Human Nutrition, Foods, and Exercise, 295 West Campus Drive, Virginia Tech, Blacksburg, VA 24061, USA; The Fralin Translational Obesity Research Center, 1981 Kraft Drive, Virginia Tech, Blacksburg, VA 24061, USA; The Metabolic Phenotyping Core, 1981 Kraft Drive, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: mcmillr@vt.edu.
Madlyn I FrisardThe Department of Human Nutrition, Foods, and Exercise, 295 West Campus Drive, Virginia Tech, Blacksburg, VA 24061, USA; The Fralin Translational Obesity Research Center, 1981 Kraft Drive, Virginia Tech, Blacksburg, VA 24061, USA; The Metabolic Phenotyping Core, 1981 Kraft Drive, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: frisardm@vt.edu.
Matthew W HulverThe Department of Human Nutrition, Foods, and Exercise, 295 West Campus Drive, Virginia Tech, Blacksburg, VA 24061, USA; The Fralin Translational Obesity Research Center, 1981 Kraft Drive, Virginia Tech, Blacksburg, VA 24061, USA; The Metabolic Phenotyping Core, 1981 Kraft Drive, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: hulvermw@vt.edu.
Virginia Tech · US

Funding

Inflammatory Regulation of Lipid Accumulation in Skeletal Muscle with ObesityR01DK078765 · NIDDK · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HULVER, MATTHEW W · 2008 to 2012
$1.7M
Inflammatory regulation of lipid accumulation in skeletal muscle with obesityR56DK078765 · NIDDK · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI HULVER, MATTHEW W · 2007 to 2007
$157k
NIDDK NIH HHS R01 DK-078765NIDDK NIH HHS R01 DK078765NIDDK NIH HHS R56 DK-078765NIDDK NIH HHS R56 DK078765
6 · The paper itself

Abstract

Obesity is associated with metabolic derangements in multiple tissues, which contribute to the progression of insulin resistance and the metabolic syndrome. The underlying stimulus for these metabolic derangements in obesity are not fully elucidated, however recent evidence in rodents and humans suggests that systemic, low level elevations of gut derived endotoxin (lipopolysaccharide, LPS) may play an important role in obesity related, whole-body and tissue specific metabolic perturbations. LPS initiates a well-characterized signaling cascade that elicits many pro- and anti-inflammatory pathways when bound to its receptor, Toll-Like Receptor 4 (TLR4). Low-grade elevation in plasma LPS has been termed "metabolic endotoxemia" and this state is associated with a heightened pro-inflammatory and oxidant environment often observed in obesity. Given the role of inflammatory and oxidative stress in the etiology of obesity related cardio-metabolic disease risk, it has been suggested that metabolic endotoxemia may serve a key mediator of metabolic derangements observed in obesity. This review provides supporting evidence of mechanistic associations with cell and animal models, and provides complimentary evidence of the clinical relevance of metabolic endotoxemia in obesity as it relates to inflammation and metabolic derangements in humans. Discrepancies with endotoxin detection are considered, and an alternate method of reporting metabolic endotoxemia is recommended until a standardized measurement protocol is set forth.

Indexed as

Oxidative StressAnimalsEndotoxemiaHumansInflammationIntestinal MucosaLipopolysaccharidesObesityToll-Like Receptor 4LipopolysaccharidesTLR4 protein, humanToll-Like Receptor 4Endotoxin detectionInflammationMetabolic endotoxemiaObesitySubstrate metabolism

Identifiers

PMID26133659
PMCPMC4695328
OpenAlexW769942964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.