ArticlePloS one2015
Blueberry Anthocyanins-Enriched Extracts Attenuate Cyclophosphamide-Induced Cardiac Injury.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Phytochemical Profiles, In Vitro Antioxidants and Antihypertensive Properties of Wild Blueberries (Foods (Basel, Switzerland) · 2025Article
- Comparative study on the protective effect of dexrazoxane and blueberry extract against doxorubicin-induced cardiotoxicity in rats.Scientific reports · 2025Article
- Article
- Purple Corn Extract Prevents Doxo-Induced Cardiotoxicity by Counteracting AMPK Activation and p53 Acetylation in HL-1 and Primary Cardiomyocytes.Oxidative medicine and cellular longevity · 2025Article
- Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review.Biomedicines · 2023Review
- β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways.Journal of cardiovascular development and disease · 2022Article
- Blueberry extract attenuates norepinephrine-induced oxidative stress and apoptosis in H9c2 cardiac cells.Molecular and cellular biochemistry · 2022Article
- Blueberry extract improves redox balance and functional parameters in the right ventricle from rats with pulmonary arterial hypertension.European journal of nutrition · 2022Article
- Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2021Review
- The Role of METTL3-Mediated N6-Methyladenosine (m6A) of JPH2 mRNA in Cyclophosphamide-Induced Cardiotoxicity.Frontiers in cardiovascular medicine · 2021Article
- Cardioprotective Effect of Crude Extract and Solvent Fractions ofJournal of experimental pharmacology · 2021Article
- Protective Effects of Anthocyanin Extract from Purple Sweet Potato (Preventive nutrition and food science · 2020Article
- The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action.Frontiers in pharmacology · 2020Review
- Daily Consumption of an Anthocyanin-Rich Extract Made From New Zealand Blackcurrants for 5 Weeks Supports Exercise Recovery Through the Management of Oxidative Stress and Inflammation: A Randomized Placebo Controlled Pilot Study.Frontiers in nutrition · 2020Article
- The Ameliorating Effect of Plasma Protein fromMarine drugs · 2019Article
- Tart Cherry Reduces Inflammation in Adipose Tissue of Zucker Fatty Rats and Cultured 3T3-L1 Adipocytes.Nutrients · 2018Article
- Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings.International journal of molecular sciences · 2018Review
- Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects.Frontiers in pharmacology · 2018Review
- Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review.Frontiers in pharmacology · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We sought to explore the effect of blueberry anthocyanins-enriched extracts (BAE) on cyclophosphamide (CTX)-induced cardiac injury. The rats were divided randomly into five groups including normal control, CTX 100 mg/kg, BAE 80mg/kg, CTX+BAE 20mg/kg and CTX+BAE 80mg/kg groups. The rats in the three BAE-treated groups were administered BAE for four weeks. Seven days after BAE administration, rats in CTX group and two BAE-treated groups were intraperitoneally injected with a single dose of 100 mg/kg CTX. Cardiac injury was assessed using physiological parameters, Echo, morphological staining, real-time PCR and western blot. In addition, cardiotoxicity indices, inflammatory cytokines expression and oxidative stress markers were also detected. Four weeks 20mg/kg and 80mg/kg dose of BAE treatment following CTX exposure attenuated mean arterial blood pressure, heart rate and activities of heart enzymes, improved cardiac dysfunction, left ventricular hypertrophy and fibrosis. Importantly, BAE also attenuated CTX-induced LV leukocyte infiltration and inflammatory cytokines expression, ameliorated oxidative stress as well as cardiomyocyte apoptosis. In conclusion, BAE attenuated the CTX-induced cardiac injury and the protective mechanisms were related closely to the anti-inflammatory, antioxidant and anti-inflammatory characteristics of BAE.
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