ArticleInternational journal of geriatric psychiatry2016
Family member deaths across adulthood predict Alzheimer's disease risk: The Cache County Study.
Article in International journal of geriatric psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The Relationship Between Adverse Childhood Experiences and Alzheimer's Disease: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
- The mediating role of life course cognitive reserve-enhancing factors in the relationship between adverse childhood experiences and dementia among older adults: evidence from a prospective cohort study in the United States.Social psychiatry and psychiatric epidemiology · 2025Article
- Childhood socio-economic circumstances and dementia: prospective register-based cohort study of adulthood socio-economic and cardiovascular health mediators.International journal of epidemiology · 2023Article
- Effect modifications of BMI transition and trajectory in the associations of adverse childhood experiences with new-onset dementia and its subtypes in older US adults.General psychiatry · 2023Article
- Sibling Deaths, Racial/Ethnic Disadvantage, and Dementia in Later Life.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Parental Death and Cognitive Impairment: An Examination by Gender and Race-Ethnicity.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008-2016.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesParental death during childhood, and offspring and spouse death during adulthood have individually been associated with faster cognitive decline and higher Alzheimer's disease (AD) risk in late life. However, the cumulative effect of childhood and adulthood family deaths on AD risk among different age cohorts has not been studied.
methodsTo examine these associations, this prospective cohort study uses a population-based sample of 4545 initially non-demented participants (56.7% female; age M = 75.0/SD = 6.9 years) observed at four triennial waves, linked with objective Utah Population Database data on cumulative mother, father, sibling, spouse, and offspring death experienced during childhood and adulthood. Cox regression modeled survival time from baseline interview to AD onset, as a function of family deaths during childhood or adulthood, among different age groups, along with gender and presence of ε4 allele at apolipoprotein E (APOE) polymorphic genetic locus.
resultsAge group significantly moderated the relationship between family death and AD; among persons aged 65-69 years at baseline (children of the Great Depression), those exposed to 3-4 deaths and 5+ deaths during adulthood exhibited a doubling of AD risk (adjusted hazard ratio, aHR = 2.25, p = .038, and aHR = 2.72, p = .029), while among persons aged 80 years and older, those exposed to 3-4 deaths during adulthood exhibited lower AD risk (HR = 0.539, p = 0.014). In a combined model of childhood and adulthood deaths, these findings persisted.
conclusionsResults suggest a cohort effect in the link between family member deaths during adulthood and AD risk later in life.
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