Evidence map›Paper›PMID 26132992›Full record

ArticleNutrients2015

Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors.

Henry J Thompson, Scot M Sedlacek, Pamela Wolfe, Devchand Paul, Susan G Lakoski, Mary C Playdon, John N McGinley, Shawna B Matthews

Open access · goldAbstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. iScience · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Weight Loss and Appetite Control in Women.Current obesity reports · 2017
    Review
  14. The Obesity-Breast Cancer Conundrum: An Analysis of the Issues.International journal of molecular sciences · 2016
    Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Henry J ThompsonCancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. henry.thompson@colostate.edu.
Scot M SedlacekCancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. scot.sedlacek@usoncology.com.
Pamela WolfeColorado Biostatistics Consortium, University of Colorado, Denver, CO 80045, USA. pamela.wolfe@ucdenver.edu.
Devchand PaulRocky Mountain Cancer Centers, Denver, CO 80220, USA. devchand.paul@usoncology.com.
Susan G LakoskiDepartment of Internal Medicine, University of Vermont, Burlington, VT 05405, USA. susan.lakoski@med.uvm.edu.
Mary C PlaydonCancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. mary.playdon@yale.edu.
John N McGinleyCancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. john.mcginley@colostate.edu.
Shawna B MatthewsCancer Prevention Laboratory, Colorado State University, Fort Collins, CO 80523-1173, USA. scomer@rams.colostate.edu.
Colorado State University · USRocky Mountain Cancer Centers · USUniversity of Colorado Denver · USUniversity of Vermont · USYale University · US

Funding

Diet Composition, Weight Control and Breast CarcinogenesisR01CA125243 · NCI · COLORADO STATE UNIVERSITY · PI THOMPSON, HENRY J · 2007 to 2011
$1.4M
NCI NIH HHS CA125243NCI NIH HHS R01 CA125243
6 · The paper itself

Abstract

Women who are obese at the time of breast cancer diagnosis have higher overall mortality than normal weight women and some evidence implicates adiponectin and leptin as contributing to prognostic disadvantage. While intentional weight loss is thought to improve prognosis, its impact on these adipokines is unclear. This study compared the pattern of change in plasma leptin and adiponectin in overweight-to-obese post-menopausal breast cancer survivors during weight loss. Given the controversies about what dietary pattern is most appropriate for breast cancer control and regulation of adipokine metabolism, the effect of a low fat versus a low carbohydrate pattern was evaluated using a non-randomized, controlled study design. Anthropometric data and fasted plasma were obtained monthly during the six-month weight loss intervention. While leptin was associated with fat mass, adiponectin was not, and the lack of correlation between leptin and adiponectin concentrations throughout weight loss implies independent mechanisms of regulation. The temporal pattern of change in leptin but not adiponectin was affected by magnitude of weight loss. Dietary pattern was without effect on either adipokine. Mechanisms not directly related to dietary pattern, weight loss, or fat mass appear to play dominant roles in the regulation of circulating levels of these adipokines.

Indexed as

AdiponectinAnthropometryBiomarkersBody Mass IndexBreast NeoplasmsDiet, Carbohydrate-RestrictedDiet, Fat-RestrictedFemaleHumansLeptinMiddle AgedOverweightPostmenopausePrognosisSurvivorsTime FactorsAdiponectinADIPOQ protein, humanBiomarkersLeptinadiponectinbody compositionbreast cancer survivorsdietary patternleptinweight loss

Identifiers

PMID26132992
PMCPMC4516992
OpenAlexW1509367344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.