ArticleInvestigative ophthalmology & visual science2015
The Effects of Increasing Ocular Surface Stimulation on Blinking and Tear Secretion.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Efficacy of blink software in improving the blink rate and dry eye symptoms in visual display terminal users - A single-blinded randomized control trial.Indian journal of ophthalmology · 2021Trial
- Ocular Surface Changes in Treatment-Naive Thyroid Eye Disease.Journal of clinical medicine · 2023Article
- Dynamic tear meniscus parameters in complete blinking: insights into dry eye assessment.International journal of ophthalmology · 2023Article
- Review on the possible pathophysiological mechanisms underlying visual display terminal-associated dry eye disease.Acta ophthalmologica · 2022Review
- Multiple Criterion and Multiple Stimulus Signal Detection Theory Analysis of Corneal Painful and Cool Pneumatic Stimuli.Frontiers in pharmacology · 2022Article
- Review
- A Method to Calibrate the Carbon Dioxide (Chemical) Stimuli of Pneumatic Esthesiometer Externally.Translational vision science & technology · 2019Article
- Blind working time in visual display terminal users.Journal of occupational health · 2019Article
- Dynamics of Fluorescent Imaging for Rapid Tear Thinning.Bulletin of mathematical biology · 2019Article
- On tear film breakup (TBU): dynamics and imaging.Mathematical medicine and biology : a journal of the IMA · 2018Article
- Mechanisms, imaging and structure of tear film breakup.The ocular surface · 2018Review
- Human Meibum Age, Lipid-Lipid Interactions and Lipid Saturation in Meibum from Infants.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo investigate the effect of varying levels of ocular surface stimulation on the timing and amplitude of the blink and tear secretion.
methodsFollowing instillation of fluorescein dye, increasing levels of air flow were directed toward the central corneas of 10 healthy subjects. Interblink interval (IBI), tear meniscus height (TMH), and fluorescence intensity were measured simultaneously. Because blinking can obscure changes in TMH, we developed novel measures of tear secretion by calculating tear meniscus fluorescein concentration (TMFC) from intensity using a mathematical model. The change of TMH and TMFC over trials and the slope of the TMFC within each IBI (IBI-TTR) were further calculated.
resultsThe mean IBI was decreased by 8.08 ± 8.54 seconds from baseline to maximum air stimulation. The TMH increase was highly variable (0.41 ± 0.39 mm) among subjects, compared to the fluorescence tear turnover metrics: decrease in TMFC of 2.84 ± 0.98 natural logarithm or ln(%) and IBI-TTR of 0.065 ± 0.032 ln(%)/sec. Ocular surface stimulation was highly correlated with the TMFC and IBI-TTR, but less so with TMH (Pearson's r = 0.71, 0.69, and 0.40, P < 0.01, respectively). Blinking and tearing were significantly correlated with each other (Pearson's r = 0.56, P < 0.01), but tearing lagged behind by an average of 6.54 ± 4.07 seconds.
conclusionsBlinking and tearing share a common origin with sensory stimulation at the ocular surface. Both showed a dose-response increase with surface stimulation and were correlated with each other. These methods can potentially be used to understand alterations in ocular surface sensory function and associated protective responses in dry eye and other disorders of the ocular surface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.