ArticleJournal of visualized experiments : JoVE2015
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart.
Article in Journal of visualized experiments : JoVE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure.Cardiovascular research · 2019Guideline
- SCAP-Exo-Integrated CA/HACC Hydrogel Promotes Diabetic Wound Repair via miR-122-Driven Macrophage Phenotypic Transition.Advanced healthcare materials · 2026Article
- Fish Swim Bladder-Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fibrin-Enriched Cardiac Extracellular Matrix Hydrogel PromotesACS biomaterials science & engineering · 2023Article
- Extracellular vesicle-loaded hydrogels for tissue repair and regeneration.Materials today. Bio · 2023Review
- Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells.The Korean journal of internal medicine · 2022Article
- Novel fusion peptides deliver exosomes to modify injectable thermo-sensitive hydrogels for bone regeneration.Materials today. Bio · 2022Article
- (Macro)molecular self-assembly for hydrogel drug delivery.Advanced drug delivery reviews · 2021Review
- Targeted delivery of extracellular vesicles in heart injury.Theranostics · 2021Review
- Validation of a novel stand-alone software tool for image guided cardiac catheter therapy.The international journal of cardiovascular imaging · 2019Article
- Injectable and protease-degradable hydrogel for siRNA sequestration and triggered delivery to the heart.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- 3D Whole-heart Myocardial Tissue Analysis.Journal of visualized experiments : JoVE · 2017Article
- Self-Healing Supramolecular Hydrogels Based on Reversible Physical Interactions.Gels (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration of lost myocardium is an important goal for future therapies because of the increasing occurrence of chronic ischemic heart failure and the limited access to donor hearts. An example of a treatment to recover the function of the heart consists of the local delivery of drugs and bioactives from a hydrogel. In this paper a method is introduced to formulate and inject a drug-loaded hydrogel non-invasively and side-specific into the pig heart using a long, flexible catheter. The use of 3-D electromechanical mapping and injection via a catheter allows side-specific treatment of the myocardium. To provide a hydrogel compatible with this catheter, a supramolecular hydrogel is used because of the convenient switching from a gel to a solution state using environmental triggers. At basic pH this ureido-pyrimidinone modified poly(ethylene glycol) acts as a Newtonian fluid which can be easily injected, but at physiological pH the solution rapidly switches into a gel. These mild switching conditions allow for the incorporation of bioactive drugs and bioactive species, such as growth factors and exosomes as we present here in both in vitro and in vivo experiments. The in vitro experiments give an on forehand indication of the gel stability and drug release, which allows for tuning of the gel and release properties before the subsequent application in vivo. This combination allows for the optimal tuning of the gel to the used bioactive compounds and species, and the injection system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.