Trial reportThe Angle orthodontist2016
Evaluation of the use of low-level laser therapy in pain control in orthodontic patients: A randomized split-mouth clinical trial.
Trial report in The Angle orthodontist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effects of Ibuprofen and Low-Level Laser Therapy on Orthodontic Pain By Means of Interleukin 1-Beta and Substance P Levels in the Gingival Crevicular Fluid
Impact of Photobiomodulation on Pain During Orthodontic Treatment
The Effect of Low-level Laser Therapy to Reduce Pain Caused by Orthodontic Separators: A Randomized, Double-blind Place-bo-controlled, Split-mouth Study
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of Low-Level Laser Therapy in Reducing Orthodontic Pain: A Systematic Review and Meta-Analysis.Pain research & management · 2017Pooled it
- Pulsed Nd:YAG versus continuous-wave laser photobiomodulation for orthodontic pain: a split-mouth RCT.Lasers in medical science · 2026Trial
- Postoperative pain after emergency pulpectomy with or without photobiomodulation in symptomatic irreversible pulpitis A randomized clinical trial.Scientific reports · 2026Trial
- Efficacy of a simplified photobiomodulation protocol in orthodontic patients: a randomized crossover clinical trial.Dental press journal of orthodontics · 2026Trial
- Evaluation of the analgesic effect of laser therapy at acupuncture points in orthodontic patients.Lasers in medical science · 2025Trial
- Effect of photobiomodulation and selective caries removal in deep cavities on postoperative sensitivity, pulp vitality and dentin neoformation: randomized clinical trial and tomographic evaluation.Clinical oral investigations · 2025Trial
- Comparative efficacy of pharmaceutical (Ibuprofen) and non-pharmaceutical (photobiomodulation, and chewing gum) interventions for pain reduction after elastomeric separator placement in orthodontic patients: a randomized clinical trial.Lasers in medical science · 2024Trial
- The effectiveness of low-level laser therapy and low-intensity pulsed ultrasound in reducing pain induced by orthodontic separation: a randomized controlled trial.BMC oral health · 2024Trial
- Effects of ibuprofen and low-level laser therapy on orthodontic pain by means of the analysis of interleukin 1-beta and substance P levels in the gingival crevicular fluid.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2021Trial
- Low-level laser therapy effectiveness in reducing initial orthodontic archwire placement pain in premolars extraction cases: a single-blind, placebo-controlled, randomized clinical trial.BMC oral health · 2020Trial
- Comparison of the effect of photobiomodulation therapy and Ibuprofen on postoperative pain after endodontic treatment: randomized, controlled, clinical study.Lasers in medical science · 2020Trial
- Effect of ozone and diode laser (635 nm) in reducing orthodontic pain in the maxillary arch-a randomized clinical controlled trial.Lasers in medical science · 2020Trial
- Effect of photobiomodulation with low-level laser therapy combined with potassium nitrate on controlling post-bleaching tooth sensitivity: clinical, randomized, controlled, double-blind, and split-mouth study.Clinical oral investigations · 2019Trial
- Clinical study on the efficacy of LED phototherapy for pain control in an orthodontic procedure.Lasers in medical science · 2019Trial
- Effect of photobiomodulation therapy on postoperative pain after endodontic treatment: a randomized, controlled, clinical study.Clinical oral investigations · 2019Trial
- Laser-Assisted Orthodontic Tooth Movement in Saudi Population: A Prospective Clinical Intervention of Low-Level Laser Therapy in the 1st Week of Pain Perception in Four Treatment Modalities.Pain research & management · 2019Trial
- Supplemental vibrational force does not reduce pain experience during initial alignment with fixed orthodontic appliances: a multicenter randomized clinical trial.Scientific reports · 2015Trial
- Review
- Efficacy of Different Regimens of 980 nm Low-Level Laser Therapy to Reduce Pain Caused by Elastomeric Separator Placement in Adults: A Randomized, Double-Blind, Split-Mouth Placebo-Controlled Study.Journal of clinical medicine · 2026Article
- Evaluation of in Vivo Effects of Low-Intensity Pulsed Ultrasound and Low-Level Laser Therapy on Premaxillary Suture During Rapid Maxillary Expansion.Turkish journal of orthodontics · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of using low-level laser therapy (LLLT) to control pain and discomfort during orthodontic treatment. MATERIALS AND
methodsA randomized, split-mouth clinical trial was conducted with 30 volunteers in need of orthodontic treatment, of both genders, aged between 18 and 40 years, who were randomly divided into two groups. One hemiarch was considered the exposed group (EG) and the other, the placebo group (PG). Both groups had elastic separators placed mesially and distally to the first molars of the two hemiarches at different times. The EG received an AIGaAs diode LLLT (810 nm, 100 mW, 2J/cm(2)) application for 15 seconds per point (interdental papilla at the mesial, distal, and near the root apex) immediately after separator placement on the maxillary right side. The PG also had elastics placed around the maxillary right molars, but received only simulated LLLT application. The elastics were left in place for 5 days, and after a waiting period of 1 week, they were inserted on the left side in both groups; however, the order of laser application was changed. While the separator remained in place, the patient marked his degree of perceived discomfort on a Visual Analog Scale (VAS) at 5 minutes (T0), 24 hours (T1), and 120 hours (T2), after LLLT application.
resultsA statistically significant difference was observed (P < .005) in reducing discomfort in the exposed group compared with the placebo group. This reduction of discomfort in the EG was observed at all time intervals.
conclusionsA sincle AIGaAs diode LLLT application may be indicated for the control or reduction of pain in the early stages of orthodontic treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.