ArticlePloS one2015
An Algorithm for Protein Helix Assignment Using Helix Geometry.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- HelixSide: A Comprehensive Method for Local and Global Orientational Analysis of Proteins.Journal of chemical information and modeling · 2026Article
- Assigning secondary structure in proteins using AI.Journal of molecular modeling · 2021Article
- [Local helix parameters fitting of proteins based on dual quaternions registration method].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018Article
- A New Secondary Structure Assignment Algorithm Using Cα Backbone Fragments.International journal of molecular sciences · 2016Article
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Authors and funding
3 authors.
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Abstract
Helices are one of the most common and were among the earliest recognized secondary structure elements in proteins. The assignment of helices in a protein underlies the analysis of its structure and function. Though the mathematical expression for a helical curve is simple, no previous assignment programs have used a genuine helical curve as a model for helix assignment. In this paper we present a two-step assignment algorithm. The first step searches for a series of bona fide helical curves each one best fits the coordinates of four successive backbone Cα atoms. The second step uses the best fit helical curves as input to make helix assignment. The application to the protein structures in the PDB (protein data bank) proves that the algorithm is able to assign accurately not only regular α-helix but also 310 and π helices as well as their left-handed versions. One salient feature of the algorithm is that the assigned helices are structurally more uniform than those by the previous programs. The structural uniformity should be useful for protein structure classification and prediction while the accurate assignment of a helix to a particular type underlies structure-function relationship in proteins.
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