ArticlePloS one2015
In-Depth Transcriptome Sequencing of Mexican Lime Trees Infected with Candidatus Phytoplasma aurantifolia.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 47 citations in OpenAlex.
- Flavescence dorée phytoplasma infection represses the transcription of the lignin pathway inFrontiers in plant science · 2026Article
- Transcriptomic Reprogramming and Key Molecular Pathways Underlying Huanglongbing Tolerance and Susceptibility in Six Citrus Cultivars.International journal of molecular sciences · 2025Article
- Comprehensive genomic and functional characterization of a phytoplasma associated with root retardation, early bolting, witches'-broom, and phyllody in daikon (Frontiers in microbiology · 2025Article
- Transcriptomic Profiling of Sugarcane White Leaf (SCWL) Canes during Maturation Phase.Plants (Basel, Switzerland) · 2024Article
- Article
- Combined transcriptome and metabolome analysis of Nerium indicum L. elaborates the key pathways that are activated in response to witches' broom disease.BMC plant biology · 2022Article
- Genome-Wide Expression Analysis of Root Tips in Contrasting Rice Genotypes Revealed Novel Candidate Genes for Water Stress Adaptation.Frontiers in plant science · 2022Article
- Phytoplasma diseases of plants: molecular diagnostics and way forward.World journal of microbiology & biotechnology · 2021Review
- Differential Response of Grapevine to Infection with 'International journal of molecular sciences · 2021Article
- Article
- Pre-symptomatic modified phytohormone profile is associated with lower phytoplasma titres in an Arabidopsis seor1ko line.Scientific reports · 2020Article
- Gene Expression Profile of Mexican Lime (Microorganisms · 2020Article
- Genome-wide analysis of three histone marks and gene expression in Paulownia fortunei with phytoplasma infection.BMC genomics · 2019Article
- Plant Hormones in Phytoplasma Infected Plants.Frontiers in plant science · 2019Review
- ceRNA Cross-Talk in Paulownia Witches' Broom Disease.International journal of molecular sciences · 2018Article
- Regulation of Long Noncoding RNAs Responsive to Phytoplasma Infection inInternational journal of genomics · 2018Article
- Article
- Lotus Base: An integrated information portal for the model legume Lotus japonicus.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Witches' broom disease of acid lime greatly affects the production of Mexican lime in Iran. It is caused by a phytoplasma (Candidatus Phytoplasma aurantifolia). However, the molecular mechanisms that underlie phytoplasma pathogenicity and the mode of interactions with host plants are largely unknown. Here, high-throughput transcriptome sequencing was conducted to explore gene expression signatures associated with phytoplasma infection in Mexican lime trees. We assembled 78,185 unique transcript sequences (unigenes) with an average length of 530 nt. Of these, 41,805 (53.4%) were annotated against the NCBI non-redundant (nr) protein database using a BLASTx search (e-value ≤ 1e-5). When the abundances of unigenes in healthy and infected plants were compared, 2,805 transcripts showed significant differences (false discovery rate ≤ 0.001 and log2 ratio ≥ 1.5). These differentially expressed genes (DEGs) were significantly enriched in 43 KEGG metabolic and regulatory pathways. The up-regulated DEGs were mainly categorized into pathways with possible implication in plant-pathogen interaction, including cell wall biogenesis and degradation, sucrose metabolism, secondary metabolism, hormone biosynthesis and signalling, amino acid and lipid metabolism, while down-regulated DEGs were predominantly enriched in ubiquitin proteolysis and oxidative phosphorylation pathways. Our analysis provides novel insight into the molecular pathways that are deregulated during the host-pathogen interaction in Mexican lime trees infected by phytoplasma. The findings can be valuable for unravelling the molecular mechanisms of plant-phytoplasma interactions and can pave the way for engineering lime trees with resistance to witches' broom disease.
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