Evidence map›Paper›PMID 26132000›Full record

ArticleCurrent protocols in human genetics2015

Using the PhenX Toolkit to Add Standard Measures to a Study.

Tabitha Hendershot, Huaqin Pan, Jonathan Haines, William R Harlan, Mary L Marazita, Catherine A McCarty, Erin M Ramos, Carol M Hamilton

Abstract read
In one paragraph

Article in Current protocols in human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Trial
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  8. Interaction BetweenKidney international reports · 2025
    Article
  9. Article
  10. Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
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  15. Article
  16. Social determinants of health data in solid organ transplantation: National data sources and future directions.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tabitha HendershotRTI International, Research Triangle Park, North Carolina.
Huaqin PanRTI International, Research Triangle Park, North Carolina.
Jonathan HainesCase Western Reserve University, Cleveland, Ohio.
William R HarlanRetired, Office of the Director, National Institutes of Health, Bethesda, Maryland.
Mary L MarazitaUniversity of Pittsburgh, Pittsburgh, Pennsylvania.
Catherine A McCartyEssentia Institute of Rural Health, Duluth, Minnesota.
Erin M RamosNational Human Genome Research Institute, Bethesda, Maryland.
Carol M HamiltonRTI International, Research Triangle Park, North Carolina.

Funding

Genomic Resource Grant for the PhenX Toolkit - expansion and sustainabilityPhenX Supplement for COVID-19 ResearchU41HG007050 · NHGRI · RESEARCH TRIANGLE INSTITUTE · PI HAMILTON, CAROL MARIE · 2013 to 2022
$21.2M
Building Consensus for Standard Measures for Genome-Wide Association StudiesU01HG004597 · NHGRI · RESEARCH TRIANGLE INSTITUTE · PI HAMILTON, CAROL MARIE · 2007 to 2012
$11.1M
NHGRI NIH HHS 3U01HG004597-02S1NHGRI NIH HHS 3U41HG007050-01S2NHGRI NIH HHS 3U41HG007050-02S3NHGRI NIH HHS 3U41HG007050-02S4NHGRI NIH HHS U01 HG004597NHGRI NIH HHS U01HG004597NHGRI NIH HHS U41 HG007050NHGRI NIH HHS U41HG007050NHGRI NIH HHS U41HG007050-02S2
6 · The paper itself

Abstract

The PhenX (consensus measures for Phenotypes and eXposures) Toolkit (https://www.phenxtoolkit.org/) offers high-quality, well-established measures of phenotypes and exposures for use by the scientific community. The goal is to promote the use of standard measures, enhance data interoperability, and help investigators identify opportunities for collaborative and translational research. The Toolkit contains 395 measures drawn from 22 research domains (fields of research), along with additional collections of measures for Substance Abuse and Addiction (SAA) research, Mental Health Research (MHR), and Tobacco Regulatory Research (TRR). Additional measures for TRR that are expected to be released in 2015 include Obesity, Eating Disorders, and Sickle Cell Disease. Measures are selected by working groups of domain experts using a consensus process that includes input from the scientific community. The Toolkit provides a description of each PhenX measure, the rationale for including it in the Toolkit, protocol(s) for collecting the measure, and supporting documentation. Users can browse measures in the Toolkit or can search the Toolkit using the Smart Query Tool or a full text search. PhenX Toolkit users select measures of interest to add to their Toolkit. Registered Toolkit users can save their Toolkit and return to it later to revise or complete. They then have options to download a customized Data Collection Worksheet that specifies the data to be collected, and a Data Dictionary that describes each variable included in the Data Collection Worksheet. The Toolkit also has a Register Your Study feature that facilitates cross-study collaboration by allowing users to find other investigators using the same PhenX measures.

Indexed as

Environmental ExposurePhenotypeUser-Computer InterfaceHumansInternetSoftwareWeb Browserenvironmental exposuresepidemiologygenome-wide association studies (GWAS)PhenX; phenotypesresearch; standard measures

Identifiers

PMID26132000
PMCPMC8029591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.