Evidence map›Paper›PMID 26131870›Full record

ArticleAnais brasileiros de dermatologia

Histopathological analysis of the therapeutic response to cryotherapy with liquid nitrogen in patients with multiple actinic keratosis.

Marina Câmara de Oliveira, Flávia Trevisan, Clovis Antônio Lopes Pinto, Célia Antônia Xavier, Jaqueline Campoi Calvo Lopes Pinto

Open access · goldAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Cryotherapy for Actinic Keratosis: Basic Principles and Literature Review.Clinical, cosmetic and investigational dermatology · 2022
    Review
  2. Article
  3. [Actinic keratoses].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2016
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Marina Câmara de OliveiraFaculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
Flávia TrevisanFaculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
Clovis Antônio Lopes PintoFaculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
Célia Antônia XavierFaculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
Jaqueline Campoi Calvo Lopes PintoFaculdade de Medicina de Jundiaí, Jundiaí, SP, Brazil.
Faculdade de Medicina de Jundiaí · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Actinic keratoses are premalignant lesions of the skin caused by excessive sun exposure. Lesions may become mainly squamous cell carcinoma. Cryotherapy with liquid nitrogen is one of the main treatments. In order to evaluate the response of actinic keratosis to cryotherapy by histopathology, two lesions were selected in each of 14 patients with multiple actinic keratoses. In one lesion a biopsy was performed and in the other lesion a biopsy was performed after cryotherapy. Subsequently, both biopsies were compared histologically. Of the thirteen patients who completed the study, the best results were obtained in lesions undergoing cryotherapy concerning the atypia of keratinocytes, epithelial thickness and corneal layer and lymphocytic infiltrate. Despite the small number of patients, it was concluded that, if performed correctly, cryotherapy has high efficacy in the treatment of actinic keratoses.

Indexed as

AdultAgedAged, 80 and overBiopsyCorneaCryotherapyDermoscopyFemaleHumansKeratinocytesKeratosis, ActinicMaleMiddle AgedNitrogenReproducibility of ResultsSkinNitrogen

Identifiers

PMID26131870
PMCPMC4516092
OpenAlexW749309494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.