Observational studyMedicine2015
Emergency Presentations With Nonspecific Complaints-the Burden of Morbidity and the Spectrum of Underlying Disease: Nonspecific Complaints and Underlying Disease.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00920491 (BANC4), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BANC4 (BASEL NON - SPECIFIC COMPLAINTS 4) Biomarker-enhanced Disposition Decisions
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nonspecific complaints in the emergency department - a systematic review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2020Pooled it
- Adrenomedullin for Risk Stratification of Emergency Patients With Nonspecific Complaints: An Interventional Multicenter Pilot Study.Medicine · 2016Trial
- [Core curriculum of intensive care and emergency medicine in internal medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Review
- Article
- Identifying diagnostic errors in the emergency department using trigger-based strategies.BMJ open quality · 2025Observational
- Evaluation of a care pathway for older adults presenting with nonspecific complaints at the emergency department: a before-and-after study.European geriatric medicine · 2025Article
- Chronic Hypoxia Due to Hypopharyngeal Cancer Presenting As Generalized Weakness: A Case Report.Cureus · 2025Article
- Association of Clinical Indicators of Acute Deterioration and Morbidity and Mortality in the Residential Aged Care Population: A Retrospective Cohort Study of Routinely Collected Health Data.Journal of evaluation in clinical practice · 2025Article
- Older hospitalised patients with a chief complaint of weakness and nonspecific presentations are not at risk of adverse health outcomes.Journal of evaluation in clinical practice · 2025Article
- Final Diagnoses of Elderly Emergency Patients Presenting with Weakness and Fatigue in Southeastern Iran.Current aging science · 2025Article
- Serious conditions among conveyed and non-conveyed patients presenting with nonspecific chief complaints to the ambulance service.BMC emergency medicine · 2024Article
- Hypothyroid-Induced Rhabdomyolysis: A Case Report.Cureus · 2024Article
- [Clinical acute and emergency medicine curriculum-focus on internal medicine : Recommendations for advanced training in internal medicine in the emergency department].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Article
- Diagnoses and mortality among prehospital emergency patients calling 112 with unclear problems: a population-based cohort study from Denmark.Scandinavian journal of trauma, resuscitation and emergency medicine · 2022Observational
- Frequency and predictors of unspecific medical diagnoses in the emergency department: a prospective observational study.BMC emergency medicine · 2022Observational
- Nonspecific symptoms dominate at first contact to emergency healthcare services among cases with invasive meningococcal disease.BMC family practice · 2021Observational
- A dangerously underrated entity? Non-specific complaints at emergency department presentation are associated with utilisation of less diagnostic resources.BMC emergency medicine · 2021Article
- Soluble urokinase plasminogen activator receptor and lactate as prognostic biomarkers in patients presenting with non-specific chief complaints in the pre-hospital setting - the PRIUS-study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Observational
- The presentational flow chart "unwell adult" of the Manchester Triage System-Curse or blessing?PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of diagnoses, morbidity, and mortality of patients with nonspecific complaints (NSC) presenting to the emergency department (ED) is unknown.To determine the prevalence of diagnoses, acute morbidity, and mortality of patients with NSC.Prospective observational study with a 30-day follow-up. Patients presenting to 2 EDs were enrolled by a study team and diagnosed according to the World Health Organization ICD-10 System.Of 217,699 presentations to the ED from May 2007 through to February 2011, a total of 1300 patients were enrolled. After exclusion of 90 patients who fulfilled exclusion criteria, 1210 patients were analyzed. No patient was lost to follow-up. In patients with NSC, the underlying diseases were spread throughout 18 chapters of the ICD-10. A total of 58.7% of the patients were diagnosed with acute morbidity. Thirty-day mortality was 6.4% overall. Patients with acute morbidity and suffering from heart failure and pneumonia had mortalities >15%; patients lacking acute morbidity, but suffering from functional impairment or depression/anxiety had mortalities of 0%. Although the history did not allow any prediction, age and sex were predictive of morbidity and mortality.The differential diagnoses in patients presenting with NSC is broad. Acute morbidity and mortality were high in the presented cohort, the predictors of morbidity and mortality being age and sex rather than the nature of the complaints. Urgently needed management strategies could be based on these results.ClinicalTrials.gov (#NCT00920491).
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