SynthesisMedicine2015
The Impact of Diabetes Mellitus on Renal Cell Carcinoma Prognosis: A Meta-Analysis of Cohort Studies.
Synthesis in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 10 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 10 syntheses or guidelines pooled it.
- Renal functional outcomes after nephrectomy in patients with localized renal cell carcinoma and diabetes mellitus: a systematic review and meta-analysis.International urology and nephrology · 2024Pooled it
- Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis.BMC cancer · 2020Pooled it
- Diabetes mellitus and survival of non-small cell lung cancer patients after surgery: A comprehensive systematic review and meta-analysis.Thoracic cancer · 2019Pooled it
- Association of diabetes mellitus with thyroid cancer risk: A meta-analysis of cohort studies.Medicine · 2017Pooled it
- Diabetes mellitus and the risk of bladder cancer: A PRISMA-compliant meta-analysis of cohort studies.Medicine · 2017Pooled it
- Diabetes mellitus and the risk of gastric cancer: a meta-analysis of cohort studies.Oncotarget · 2017Pooled it
- The impact of metformin use on survival in kidney cancer patients with diabetes: a meta-analysis.International urology and nephrology · 2017 · on this mapPooled it
- The Effect of Diabetes Mellitus on Lung Cancer Prognosis: A PRISMA-compliant Meta-analysis of Cohort Studies.Medicine · 2016Pooled it
- Diabetes mellitus and the risk of glioma: a meta-analysis.Oncotarget · 2016Pooled it
- Preoperative serum total cholesterol is a predictor of prognosis in patients with renal cell carcinoma: a meta- analysis of observational studies.International braz j urol : official journal of the Brazilian Society of UrologyPooled it
- Impact of metabolic syndrome and its components on the tumor aggressiveness of renal cell carcinoma.Medicine · 2026Observational
- Prevalence of diabetes and hospitalization due to poor glycemic control in people with bladder cancer or renal cell carcinoma in Sweden.BMC urology · 2024Article
- Article
- Effect of smoking, hypertension and lifestyle factors on kidney cancer - perspectives for prevention and screening programmes.Nature reviews. Urology · 2023Review
- Primary and Immortalized Cultures of Human Proximal Tubule Cells Possess Both Progenitor and Non-Progenitor Cells That Can Impact Experimental Results.Journal of personalized medicine · 2023Article
- Effects of metabolic syndrome on renal function after radical nephrectomy in patients with renal cell carcinoma.International urology and nephrology · 2021Article
- Development and Validation of a Nomogram Predicting the Prognosis of Renal Cell Carcinoma After Nephrectomy.Cancer management and research · 2020Article
- Does diabetes mellitus play an independent prognostic role in kidney cancer?Annals of translational medicine · 2019Article
- The prognostic significance of preexisting diabetes in patients with surgically treated renal cell carcinoma: the ongoing debate.Annals of translational medicine · 2019Article
- Metabolic Syndrome Resolved within Two Years is Still a Risk Factor for Kidney Cancer.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies that investigated the relationship between DM and survival in renal cell carcinoma (RCC) patients reported inconsistent findings. Hence, we conducted a meta-analysis to obtain a more precise evaluation of the prognostic significance of DM in RCC. A systematic review was conducted with PubMed, Embase, and Web of Science to identify relevant articles that evaluated the effect of DM on RCC patients. Based on the inclusion and quality assessment criteria, 18 studies were eligible for the meta-analysis. Pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI) for overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were calculated by standard meta-analysis techniques. The results suggested that DM was associated with poor OS (HR 1.56, 95% CI, 1.35-1.81, P < 0.001), poor CSS (HR 2.03, 95% CI, 1.37-3.01, P < 0.001), and poor RFS (HR 1.73, 95% CI, 1.25-2.39, P = 0.012). In addition, for patients with localized RCC, patients with clear cell RCC, or patients receiving nephrectomy, DM was associated with both poor OS and CSS by subgroup analyses. Our study revealed that there was a significant negative impact of DM on OS, CSS, and RFS in RCC patients. Therefore, more attention should be paid to RCC patients with preexisting DM because of their poor prognosis.
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