ArticleInternational journal of clinical and experimental medicine2015
Citrate metabolism in blood transfusions and its relationship due to metabolic alkalosis and respiratory acidosis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Hypocalcaemia upon arrival (HUA) in trauma patients who did and did not receive prehospital blood products: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Pooled it
- Association Between Preoperative Calcium Levels and the Occurrence of Postoperative PE in Trauma Patients: A Retrospective Multicenter Cohort Study.World journal of surgery · 2026Article
- Pre-Hospital Calcium Administration Reduces Incidence of Hypocalcemia and Mortality in Trauma Patients.Open access emergency medicine : OAEM · 2026Article
- Early Hypercalcemia Is Associated With Mortality in Critically Ill, Transfused Trauma Patients.The Journal of surgical research · 2025Article
- Establishing a mathematical standard model for calculating the volume of peripheral arteriovenous synchronous blood exchange transfusion in neonates with severe hyperbilirubinemia.Pakistan journal of medical sciences · 2025Article
- Veterinary Perspectives on Hemoglobin-Based Oxygen Carriers in Experimental Hemorrhagic Shock: Insights from Rabbit Models.Veterinary sciences · 2025Article
- Ionised calcium levels during trauma resuscitation in predicting outcomes-a prospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Comparison of the lethal triad and the lethal diamond in severe trauma patients: a multicenter cohort.World journal of emergency surgery : WJES · 2025Article
- Association between hypocalcemia and mortality in trauma patients: a systematic review and meta-analysis.Trauma surgery & acute care open · 2025Article
- Ratios of calcium to citrate administration in blood transfusion for traumatic hemorrhage: A retrospective cohort study.Transfusion · 2024Article
- Doing more with less: low-titer group O whole blood resulted in less total transfusions and an independent association with survival in adults with severe traumatic hemorrhage.Journal of thrombosis and haemostasis : JTH · 2024Observational
- Standardised Critical Care Strategies Improve Outcomes Following Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in an Indian Peritoneal Malignancy Centre.Indian journal of surgical oncology · 2023Article
- Impact of Transfused Citrate on Pathophysiology in Massive Transfusion.Critical care explorations · 2023Review
- The Incidence, Degree, and Timing of Hypocalcemia From Massive Transfusion: A Retrospective Review.Cureus · 2022Article
- The Dietary Approach to the Treatment of the Rare Genetic Tubulopathies Gitelman's and Bartter's Syndromes.Nutrients · 2021Review
- Oral treatment with a chemically characterized parsley (Journal of traditional and complementary medicine · 2021Article
- Metabolic Bone Disease of Prematurity: Risk Factors and Associated Short-Term Outcomes.Nutrients · 2020Observational
- Urine Recirculation Improves Hemodynamics and Enhances Function in Normothermic Kidney Perfusion.Transplantation direct · 2020Article
- Plasma Citrate Homeostasis: How It Is Regulated; And Its Physiological and Clinical Implications. An Important, But Neglected, Relationship in Medicine.HSOA journal of human endocrinology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic alkalosis commonly results from excessive hydrochloric acid (HCl), potassium (K(+)) and water (H2O) loss from the stomach or through the urine. The plasma anion gap increases in non-hypoproteinemic metabolic alkalosis due to an increased negative charge equivalent on albumin and the free ionized calcium (Ca(++)) content of plasma decreases. The mean citrate load in all patients was 8740±7027 mg from 6937±6603 mL of transfused blood products. The citrate load was significantly higher in patients with alkalosis (9164±4870 vs. 7809±3967, P < 0.05). The estimated mean total citrate administered via blood and blood products was calculated as 43.2±34.19 mg/kilogram/day. In non-massive and frequent blood transfusions, the elevated carbon dioxide output has been shown to occur. Due to citrate metabolism causes intracellular acidosis. As a result of intracellular acidosis compensation, decompensated metabolic alkalosis + respiratory acidosis and electrolyte imbalance may develop, blood transfusions may result in certain complications.
Indexed as
Identifiers
26131288PMC4483798W2396636543What OpenQuestion holds
Registered trials
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