ArticleInternational journal of clinical and experimental medicine2015
Saikosaponin-d protects renal tubular epithelial cell against high glucose induced injury through modulation of SIRT3.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications.Pharmaceutical biology · 2017Pooled it
- Therapeutic Potential of Saikosaponins in MASLD and Cross-Organ Protection: A Research Update.Food science & nutrition · 2026Review
- Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review).International journal of molecular medicine · 2025Review
- Saikosaponin d (SSD) alleviates diabetic peripheral neuropathy by regulating the AQP1/RhoA/ROCK signaling in streptozotocin-induced diabetic rats.Acta diabetologica · 2023Article
- Chemotherapeutic Potential of Saikosaponin D: Experimental Evidence.Journal of xenobiotics · 2022Review
- Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition.Molecular and cellular biology · 2021Article
- Saikosaponin D inhibits proliferation of human osteosarcoma cells via the p53 signaling pathway.Experimental and therapeutic medicine · 2019Article
- A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins.Phytomedicine : international journal of phytotherapy and phytopharmacology · 2018Review
- Estrogen receptor‑β‑dependent effects of saikosaponin‑d on the suppression of oxidative stress‑induced rat hepatic stellate cell activation.International journal of molecular medicine · 2018Article
- The Role of Saikosaponins in Therapeutic Strategies for Age-Related Diseases.Oxidative medicine and cellular longevity · 2018Review
- Anti-Inflammation Effects and Potential Mechanism of Saikosaponins by Regulating Nicotinate and Nicotinamide Metabolism and Arachidonic Acid Metabolism.Inflammation · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saikosaponin-d (Ssd) is one of the major pharmacologically active molecules present in Bupleurum falcatum L, a medical herb against inflammatory diseases in the traditional Chinese medicine. In the current study, we investigated the protective activity of Ssd on diabetic nephropathy along with the underlying mechanisms using renal tubular epithelial cell line (NRK-52E). Our study showed that high glucose stimulation significantly increased NRK-52E cell proliferation. Ssd administration dramatically inhibited high glucose-induced proliferation and DNA synthesis in NRK-52E cell. In addition, high glucose treatment resulted in oxidative stress as shown by increased production of ROS, higher concentration of MDA, and decreased activity of SOD. However, incubation with Ssd reversed such changes in NRK-52E cells. On the molecular level, Ssd also increased the mRNA levels of IDH2 and MnSOD. Moreover, Ssd-treated NRK-52E cells displayed a dramatic enhancement in SIRT3 expression both at mRNA and protein levels. Down-regulation of SIRT3 abolished the protective effects of Ssd on NRK-52E cells. These findings demonstrated that Ssd protected renal tubular epithelial cell against high glucose induced injury via upregulation of SIRT3.
Indexed as
Identifiers
26131275PMC4483897W2462643753What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.