ArticleInternational journal of clinical and experimental medicine2015
Decreased expression of stem cell factor mRNA and protein in the gallbladders of guinea pigs fed on high cholesterol diet.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 6 citations in OpenAlex.
- Changes in the interstitial cells of Cajal in the gallbladder of guinea pigs fed a lithogenic diet.Experimental and therapeutic medicine · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSufficient evidence suggests that the c-kit protooncogene receptor and its ligand stem cell factor (scf) signal pathway play a crucial role in interstitial cells of Cajal (ICCs) development and maintenance of their phenotype. We aimed to determine the expressions of scf mRNA and scf protein in the gallbladders in guinea pigs fed on high cholesterol diet (HCD).
methodsThe gallbladder and serum samples from 20 guinea pigs of HCD and from 20 guinea pigs of standard diet (StD) were used for this study. Serum lipid analysis was performed using standard laboratory procedure. Expression of scf mRNA was detected by reverse transcription polymerase chain reaction (RT-PCR), and expression of scf protein was detected by Western blot analysis.
resultsLaboratory results showed serum total cholesterol (TC), low density lipoprotein (LDL) cholesterol , high density lipoprotein (HDL) cholesterol and triglyceride (TG) concentrations were significantly higher in the HCD group than in the StD group of guinea pigs (P < 0.001, respectively). Decreased expression of scf mRNA and protein were demonstrated in the HCD group compared with the StD group (P < 0.05 respectively).
conclusionThe data indicates that the expression of scf mRNA and c-kit protein is significantly decreased in the gallbladders in guinea pigs of HCD.
Indexed as
Identifiers
26131262PMC4483813W2408720803What OpenQuestion holds
Registered trials
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