ArticleInternational journal of clinical and experimental medicine2015
Correlation of HLA-DQB1 gene polymorphism of Xinjiang Uygur with outcome of HBV infection.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- HLA-DQB1*03:01 and risk of HBV-related HCC.Hepatology (Baltimore, Md.) · 2026Article
- Molecular Analysis of HLA Genes in Romanian Patients with Chronic Hepatitis B Virus Infection.Current issues in molecular biology · 2024Article
- Association of HLADQ-B1 polymorphisms in three generations of chronic hepatitis B patients.Virus research · 2023Article
- Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population.Frontiers in genetics · 2022Article
- The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection.Journal of translational medicine · 2018Article
- [Host factors influencing the clinical outcome of chronic hepatitis B virus infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017Article
- Correlation Between HLA-A, B and DRB1 Alleles and Severe Fever with Thrombocytopenia Syndrome.PLoS neglected tropical diseases · 2016Article
- Association between theBiomedical reports · 2016Article
- Clinical Relevance of HLA Gene Variants in HBV Infection.Journal of immunology research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to explore the correlation of gene polymorphisms of human leukocyte antigen-DQB1 (HLA-DQB1) with the infection outcome and replication status of hepatitis B virus (HBV) positive patients in the Xinjiang Uygur population in China.
methods110 cases of chronic hepatitis B (CHB) of Xinjiang Uygur were examined clinically, which were named as the CHB group; 100 cases carrying chronic HBV (ASC) served as ASC group; 80 cases of self-limited HBV infection (RHBS) were recorded as RHBS group. Genotypes of HLA-DQB1 were detected by sequence specific primer-polymerase chain reaction (PCR-SSP) method, and the differences of gene frequency among groups were also compared. The distribution frequencies of the HLA-DQB1 gene under different replication states of HBV were compared.
resultsThe distribution frequency of DQB1*0201 in the RHBS group was higher than that of the ASC group (18.75%, 10.50%, χ(2) = 5.959, P < 0.05, OR = 2.257). The distribution frequency of DQB1*0201 in the CHB group was higher than that of the ASC group (17.73%, 10.50%, χ(2) = 5.363, P < 0.05, OR = 2.066). The distribution frequency of DQB1*0301 in the CHB group was higher than that of the ASC group (26.82%, 16.50%, χ(2) = 9.062, P < 0.05, OR = 2.349). The distribution frequency of DQB1*0303 in the CHB group was lower than that of the ASC group (19.55%, 31.00%, χ(2) = 10.996, P < 0.05, OR = 0.393). There was no statistically significant difference in the allele frequencies among all other groups. The distribution frequency of DQB1*0201 in the low replication group was higher than that of the high replication group (17.08%, 10.56%, χ(2) = 4.295, P < 0.05, OR = 1.939).
conclusionHLA-DQB1*0201 is a HBV resistance gene in Xinjiang Uygur. DQB1*0301 is correlated with continuous infection of HBV. DQB1*0303 is a susceptibility gene of ASC.
Indexed as
Identifiers
26131205PMC4483970W2412231104What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.