ArticleInternational journal of clinical and experimental medicine2015
Genetic association of NQO1 609C>T polymorphism with risk of gastrointestinal cancer: evidence from case-control studies.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- The Analysis of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Polish Patients with Colorectal Cancer.Biomolecules · 2021Article
- Short-term Exposure to 50-Hz Electromagnetic Field and Alterations inOpen access Macedonian journal of medical sciences · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous studies have evaluated the association between NQO1 609C>T polymorphism and gastrointestinal (GI) cancer. However, the results remain inconclusive. To obtain a more precise estimation of the relation, we conducted an analysis of all available case-control studies.
methodsEligible studies were identified by searching the databases and finally 19 articles were included in the meta-analysis. Odds ratio (OR) with 95% confidence interval (95% CI) was applied to assess the association between NQO1 609C>T polymorphism and GI cancer risk. Z test was used to evaluate the significance of OR and 95% CI.
resultsIn the overall analysis, there existed a significant association between NQO1 609C>T polymorphism and GI cancer susceptibility (T vs. C: OR = 1.07, 95% CI = 1.01-1.14). The subgroup analysis based on ethnicity showed that NQO1 609C>T polymorphism was associated with susceptibility to GI cancer in mixed population (TT vs. CC: OR = 2.21, 95% CI = 1.44-3.40; TT vs. CT + CC: OR = 2.26, 95% CI = 1.48-3.44; Allele T vs. Allele C: OR = 1.24, 95% CI = 1.05-1.47). For the subgroup analysis according to source of control, a remark relationship of 609C>T with increased risk of GI cancer was observed in HB population (Allele T vs. Allele C: OR = 1.07, 95% CI = 1.01-1.14).
conclusionOur results demonstrated that NQO1 609C>T polymorphism might be associated with susceptibility to GI cancer.
Indexed as
Identifiers
26131202PMC4484002W2419630912What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.