ArticleInternational journal of clinical and experimental medicine2015
GPIbα reflects the development and progress of the patients with severe preeclampsia.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Von Willebrand disease (VWD) and pregnancy: a comprehensive overview.Thrombosis journal · 2025Review
- Circulating extracellular vesicles and neutrophil extracellular traps contribute to endothelial dysfunction in preeclampsia.Frontiers in immunology · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledPreeclampsia (PE) is a pregnancy-specific syndrome that occurs in a previously normotensive woman. Some data suggested that the activation parameters of platelets in preeclampsia. The aim of this study is to determine whether the levels of GPIbα and GPIIb for patients with preeclampsia were enhanced after cesarean section. In this study, detecting levels of GPIbα and GPIIb by flow cytometry (FCM). The venous blood of 48 severe preeclampsia women, 16 mild preeclampsia and 22 normotensive women, were collected before operation and 72 hours after the operation. Blood samples were obtained also from 20 non-pregnant women.
resultsThe level of GPIbα of the normotensive pregnancy was lower than the control group, but there was no significance (P > 0.05). The level of GPIbα of the severe preeclampsia group was much lower than other groups (P < 0.01). In the severe preeclampsia group, the level of GPIbα of postoperative patients was higher than preoperative patients (P < 0.01). There was no significance of GPIIb levels between each group (P > 0.05). In conclusion, GPIbα was an important index of reflecting the change of severe preeclampsia. Detecting the levels of GPIbα plays an important role in observing the development of this disease and guiding clinical treatment.
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Identifiers
26131201PMC4483978W2409105955What OpenQuestion holds
Registered trials
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