ArticleInternational journal of clinical and experimental medicine2015
Prospective validation of an ultrasound-based thyroid imaging reporting and data system (TI-RADS) on 3980 thyroid nodules.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Comparison of diagnostic performance of two ultrasound risk stratification systems for thyroid nodules: a systematic review and meta-analysis.La Radiologia medica · 2023Pooled it
- Accuracy of Ultrasound Diagnosis of Benign and Malignant Thyroid Nodules: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Comparison of Diagnostic Performance of Five Different Ultrasound TI-RADS Classification Guidelines for Thyroid Nodules.Frontiers in oncology · 2020Pooled it
- Use of the Kwak Thyroid Image Reporting and Data System (K-TIRADS) in differential diagnosis of thyroid nodules: systematic review and meta-analysis.European radiology · 2018Pooled it
- Accelerating the Radiology Learning Curve: How the Parameter-Based I-TIRADS Lexicon Enhances Interpretive Reliability and Learning Curves Across Resident Experience Levels-A Dynamic Video-Based Study.Diagnostics (Basel, Switzerland) · 2026Article
- Preoperative anti-thyroid antibodies predict malignancy risk in cytologically indeterminate thyroid nodules: a prospective multicenter study.Gland surgery · 2025Article
- Clinicopathological and Radiological Correlation Among the Spectrum of Nodular Thyroid Lesions.Cureus · 2024Article
- Article
- The impact of thyroid imaging reporting and data system on the management of Bethesda III thyroid nodules.Journal of Taibah University Medical Sciences · 2023Article
- Review
- Review
- The impact of the ultrasound classification on the rate of thyroid surgery indications: a 577 cases series.Journal of ultrasound · 2022Article
- Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules.Saudi medical journal · 2022Article
- The value of neutrophil-to-lymphocyte ratio combined with the thyroid imaging reporting and data system in the diagnosis of the nature of thyroid nodules.Journal of clinical laboratory analysis · 2022Article
- Influence of Hashimoto thyroiditis on diagnosis and treatment of thyroid nodules.Frontiers in endocrinology · 2022Article
- The impact of TI-RADS in detecting thyroid malignancies: a prospective study.La Radiologia medica · 2021Article
- Review
- Development and validation of circulating tumor cells signatures for papillary thyroid cancer diagnosis: A prospective, blinded, multicenter study.Clinical and translational medicine · 2020Article
- Review
- Plasma miR-323 as a Biomarker for Screening Papillary Thyroid Cancer From Healthy Controls.Frontiers in medicine · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveUltrasound (US) features of solidity, hypoechogenicity or marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, and taller-than-wide shape are suspicious characteristics for thyroid nodules. An US based Thyroid Imaging Reporting and Data System (TI-RADS) is classified based on the number of aforesaid features. TI-RADS category 3 included nodules without any suspicious features, and categories 4a, 4b, 4c, and 5 included nodules with one, two, three or four, or five suspicious US features. The purpose of the study was to prospectively validate the effectiveness of the TI-RADS.
methodsFrom October 2011 to June 2013, we prospectively categorized 3980 thyroid nodules (3752 benign and 228 malignant lesions) in 2921 patients using TI-RADS classification. TI-RADS categories 2 and 3 were considered as benign whereas TI-RADS categories 4 and 5 as malignant. The sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV) and accuracy were calculated.
resultsOf the 3980 nodules, 2953 nodules were TI-RADS category 2 (0% malignancy), 466 nodules TI-RADS category 3 (1.3% malignancy), 186 nodules TI-RADS category 4a (4.8% malignancy), 165 nodules TI-RADS category 4b (30.3% malignancy), 188 nodules TI-RADS category 4c (75.5% malignancy), and 22 nodules TI-RADS category 5 (95.5% malignancy). The sensitivity, specificity, PPV, NPV and accuracy were 97%, 90%, 40%, 99%, and 91%, respectively.
conclusionsTI-RADS classification had great diagnostic value in diagnosing thyroid nodules. The actual probability of malignancy was in accord with the theory risk of malignancy.
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Registered trials
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