ArticleInternational journal of clinical and experimental medicine2015
Association between COL1A1 polymorphisms and high myopia: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Genetic susceptibility to high myopia in Han Chinese population.Open life sciences · 2022Article
- Genipin inhibits the scleral expression of miR-29 and MMP2 and promotes COL1A1 expression in myopic eyes of guinea pigs.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Evaluation of 10 AMD Associated Polymorphisms as a Cause of Choroidal Neovascularization in Highly Myopic Eyes.PloS one · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies of the association between COL1A1 polymorphisms and high myopia risk have yielded conflicting results. To help resolve the discrepancies, we performed a meta-analysis to estimate the relationship between COL1A1 polymorphisms and high myopia risk.
methodsWe searched for case-control and cohort studies in MEDLINE, EMBASE, and OVID. Odds ratios (OR) with 95% confidence intervals (CI) were derived for single-nucleotide polymorphisms (SNPs). We also analyzed heterogeneity and publication bias.
resultsThis meta-analysis was based on five studies of rs2075555 (1,944 high myopia cases and 3,060 controls), and three studies of rs2269336 (1,454 high myopia cases and 1,512 controls). The combined results showed an association between rs2075555 and high myopia in the dominant (OR = 0.86, 95% CI = 0.71-0.99) and homozygote models (OR = 0.79, 95% CI = 0.64-0.97). In the recessive model for rs2269336, OR was 1.26 (95% CI = 1.05-1.50); in the heterozygote model, OR was 0.81 (95% CI = 0.69-0.96). Begg's and Egger's tests for rs2075555 showed no evidence of publication bias.
conclusionsThis meta-analysis suggests COL1A1 rs2075555 is a potential low risk factor for high myopia.
Indexed as
Identifiers
26131177PMC4483928W2414323279What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.